Preventative oral methylthioadenosine is anti-inflammatory and reduces DSS-induced colitis in mice.

American Journal of Physiology. Gastrointestinal and Liver Physiology
Nancy M BenightDouglas G Burrin

Abstract

Methylthioadenosine (MTA) is a precursor of the methionine salvage pathway and has been shown to have anti-inflammatory properties in various models of acute and chronic inflammation. However, the anti-inflammatory properties of MTA in models of intestinal inflammation are not defined. We hypothesized that orally administered MTA would be bioavailable and reduce morbidity associated with experimental colitis. We examined clinical, histological, and molecular markers of disease in mice provided oral MTA before (preventative) or after (therapy) the induction of colitis with 3% dextran sulfate sodium (DSS). We found a reduction in disease activity, weight loss, myeloperoxidase activity, and histological damage in mice given preventative MTA compared with DSS alone. We also found that equivalent supplementation with methionine could not reproduce the anti-inflammatory effects of MTA, and that MTA had no detectable adverse effects in control or DSS mice. Expression microarray analysis of colonic tissue showed several dominant pathways related to inflammatory cytokines/chemokines and extracellular matrix remodeling were upregulation by DSS and suppressed in MTA-supplemented mice. MTA is rapidly absorbed in the gastrointestinal tract ...Continue Reading

References

Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P A Maher
Mar 1, 1986·The Biochemical Journal·A E Pegg
Jul 15, 1983·Analytical Biochemistry·K SuzukiT Fujikura
Jan 19, 1983·Biochimica Et Biophysica Acta·M Cartenì-FarinaV Zappia
Mar 1, 1994·The Journal of Nutrition·G Wu, D A Knabe
Dec 9, 1998·Clinical and Experimental Immunology·L A DielemanE P Van Rees
Aug 1, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·B StollD G Burrin
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eduardo AnsorenaMatías A Avila
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Henar HeviaMatías A Avila
Jan 19, 2005·The Biochemical Journal·Stéphane RichardPatrick Cléroux
Apr 29, 2006·The Journal of Pharmacology and Experimental Therapeutics·Carlos Medina, Marek W Radomski
Jun 21, 2006·Annals of Neurology·Beatriz MorenoPablo Villoslada
Jul 13, 2006·Gastroenterology·Maria Van der SluisAlexandra W C Einerhand
Aug 30, 2006·Scandinavian Journal of Gastroenterology·Francisco J VizosoRichard R R Gava
Oct 13, 2006·World Journal of Gastroenterology : WJG·Peter-Laszlo Lakatos
Jan 9, 2007·Inflammatory Bowel Diseases·Anupama RaviShanthi V Sitaraman
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jul 31, 2010·Multiple Sclerosis : Clinical and Laboratory Research·B MorenoP Villoslada
Mar 23, 2011·Pathology International·Kenji SuzukiHitoshi Asakura
May 21, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nancy M BenightDouglas G Burrin

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Citations

Nov 7, 2016·Toxicologic Pathology·Rani S Sellers
May 20, 2015·Inflammatory Bowel Diseases·Michael BramhallSheena Cruickshank
Jun 6, 2018·Infection and Immunity·Jeffrey S BourgeoisDennis C Ko
Jan 13, 2015·International Journal of Immunopathology and Pharmacology·R ToumiC Touil-Boukoffa

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