Preventing autoimmune and infection triggered atherosclerosis for an enduring healthful lifestyle

Autoimmunity Reviews
Eiji MatsuuraLuis R Lopez

Abstract

Atherosclerosis is a chronic inflammatory disease of the arteries associated with various risk factors that promote lipid abnormalities (i.e., dyslipidemia), development and progression of atherosclerotic lesions, plaque rupture, and vascular thrombosis. Experimental evidence from biochemical and clinical studies support the idea that arterial thrombosis is an autoimmune process resulting from 'autoantibody'-mediated pro-atherogenic mechanisms now seen in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). In addition, it has been shown that persistent infections of Chlamydia pneumoniae (C. pneumoniae), Porphyromonas gingivalis (P. gingivalis), and Helicobacter pylori (H. pylori) cause immune responses (infectious immunity) in their hosts that promote atherogenesis. In this article, we review recent progress in our understanding of immune- and infection-mediated atherosclerosis.

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Citations

Nov 6, 2008·Clinical Reviews in Allergy & Immunology·Eiji Matsuura
Dec 11, 2008·Clinical Reviews in Allergy & Immunology·Sonja PraprotnikBlaz Rozman
May 8, 1999·Immunology Letters·M Abu-ShakraY Shoenfeld
Aug 20, 2010·The Open Neurology Journal·G SilvestrelliA Lanari
Dec 11, 2013·Mediators of Inflammation·Elisabetta ProfumoRachele Riganò
Jul 15, 2011·International Journal of Inflammation·Elisabetta ProfumoRachele Riganò
Oct 12, 2010·Journal of Biomedicine & Biotechnology·Chary López-PedreraMaria José Cuadrado
Jan 28, 2009·Current Rheumatology Reports·Eiji MatsuuraLuis R Lopez
Aug 3, 2010·Journal of Autoimmunity·Pierre Youinou
Jan 9, 2010·Journal of Autoimmunity·Pierre YouinouYehuda Shoenfeld
Jul 5, 2008·Autoimmunity Reviews·Elena OrtonaWalter Malorni
Feb 1, 2009·Proteomics. Clinical Applications·Chary López-PedreraJose Manuel Villalba
Apr 10, 2010·International Journal of Immunopathology and Pharmacology·E ProfumoR Riganò

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