PMID: 16641837Apr 28, 2006Paper

Preventing clinical deterioration in the course of schizophrenia: the potential for neuroprotection

CNS Spectrums
Jeffrey A LiebermanL Fredrik Jarskog

Abstract

Schizophrenia, which has both genetic and environmental causes, is associated with persistent symptoms and severe functional disability. The illness lies dormant during the premorbid phase and begins to express itself during adolescence or early adulthood. Clinical progression and deterioration reaches a plateau in which the patient is said to be in the chronic phase of illness and at which point restoration of prior functioning is unlikely. The severe deficits associated with schizophrenia are often the result of progression of illness due to lack of appropriate treatment. However, recent advances in neuropsychiatry have led to very early identification of individuals at risk for psychosis, even during the prodromal stage when psychosis has not yet manifested clinically. While research has demonstrated that the efficacy of antipsychotics is limited when used during the chronic phase of illness, these medications can effectively control symptoms and prevent progression of illness when used during the early stages of illness. The evidence of neural degeneration in the pathophysiology of schizophrenic illness suggests that there may be treatment opportunities through neural protection. Neuroprotection, which refers to treatment t...Continue Reading

Citations

Aug 15, 2006·Schizophrenia Bulletin·William Spaulding, Jeffrey Nolting
Sep 11, 2009·CNS Drugs·Kayvon SalimiJeffrey A Lieberman
Mar 31, 2009·Schizophrenia Research·Rajiv TandonMatcheri S Keshavan
Oct 13, 2015·Pharmacology, Biochemistry, and Behavior·Nishant S JainLokesh Verma
Jul 27, 2010·Schizophrenia Research·Rajiv TandonMatcheri S Keshavan
Mar 17, 2012·Psychiatry Research·Ilja SpellmannHans-Jürgen Möller
Feb 6, 2016·The Cochrane Database of Systematic Reviews·Pedro V S MagalhãesFlávio Kapczinski
Sep 12, 2012·Schizophrenia Research and Treatment·Benjamin RollandRégis Bordet

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