Preventing growth of brain tumors by creating a zone of resistance.

Molecular Therapy : the Journal of the American Society of Gene Therapy
C A MaguireM Sena-Esteves

Abstract

Glioblastoma multiforme (GBM) is a devastating form of brain cancer for which there is no effective treatment. Here, we report a novel approach to brain tumor therapy through genetic modification of normal brain cells to block tumor growth and effect tumor regression. Previous studies have focused on the use of vector-based gene therapy for GBM by direct intratumoral injection with expression of therapeutic proteins by tumor cells themselves. However, as antitumor proteins are generally lethal to tumor cells, the therapeutic reservoir is rapidly depleted, allowing escape of residual tumor cells. Moreover, it has been difficult to achieve consistent transduction of these highly heterogeneous tumors. In our studies, we found that transduction of normal cells in the brain with an adeno-associated virus (AAV) vector encoding interferon-beta (IFN-beta) was sufficient to completely prevent tumor growth in orthotopic xenograft models of GBM, even in the contralateral hemisphere. In addition, complete eradication of established tumors was achieved through expression of IFN-beta by neurons using a neuronal-restricted promoter. To our knowledge this is the first direct demonstration of the efficacy of targeting gene delivery exclusively ...Continue Reading

References

Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·K E WallnerM G Malkin
Jan 1, 1995·Journal of Neuropathology and Experimental Neurology·T KashimaA T Campagnoni
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·R NishikawaH J Huang
Mar 21, 2001·Human Molecular Genetics·P Y Lam, X O Breakefield
Jan 7, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Campbell KaynorXiao-Qiang Qin
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Geoffrey BowersJeffrey J Olson
Sep 23, 2003·Gene Therapy·Charles H ViteJohn H Wolfe
Oct 10, 2003·Oncogene·Khalid ShahRalph Weissleder
May 28, 2004·Journal of Virology·Guangping GaoJames M Wilson
Nov 16, 2004·Journal of Virological Methods·Miguel Sena-EstevesAlan W Flake
Nov 18, 2004·Cancer Science·Jun YoshidaToshihiko Wakabayashi
Jun 1, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Khalid ShahRalph Weissleder
Jun 2, 2005·Cancer Letters·Christian J StreckAndrew M Davidoff
Jun 25, 2005·Current Gene Therapy·Thomas J McCown
Dec 6, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ronald L KleinRichard M Zweig
Jan 18, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ronald J MandelCorinna Burger
Jan 18, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Cassia N Cearley, John H Wolfe
Apr 4, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Thomas C HardingKarin Jooss
May 24, 2006·Annals of Neurology·Carine CironJean-Michel Heard
Jul 11, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Krystof S BankiewiczJanet Cunningham
Jul 13, 2006·Expert Review of Anticancer Therapy·Sith Sathornsumetee, Jeremy N Rich
Mar 9, 2007·Human Gene Therapy·Jean-Marc TaymansVeerle Baekelandt
Oct 24, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ronald L KleinPhillip P Henning
Jan 9, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·E Antonio ChioccaDavid Kirn

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Citations

Jul 21, 2009·Journal of Neuro-oncology·Casey A MaguireMiguel Sena-Esteves
Nov 17, 2009·Cancer Gene Therapy·E RavetP Cordelier
Feb 9, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Casey A MaguireJohan Skog
Jun 20, 2013·Molecular Therapy. Nucleic Acids·Casey A MaguireBakhos A Tannous
Mar 25, 2011·Human Molecular Genetics·William J BowersMiguel Sena-Esteves
Dec 15, 2010·Future Oncology·Erik Hp van PuttenMartine Lm Lamfers
Sep 5, 2013·Journal of Neuro-oncology·Nadia A AtaiCasey A Maguire
Aug 28, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Casey A MaguireXandra O Breakefield
Jan 23, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jorge L Santiago-Ortiz, David V Schaffer
Feb 7, 2013·International Journal of Pharmaceutics·Cheng Zhe BaiJong-Sang Park
Jan 17, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yi GongFlorian S Eichler
May 20, 2016·Neuro-oncology·Dwijit GuhaSarkarMiguel Sena-Esteves
Jul 7, 2016·Molecular Therapy Oncolytics·Matheus Hw CrommentuijnBakhos A Tannous
May 17, 2018·Journal of Neuro-oncology·Adrienn VolakCasey A Maguire
May 12, 2009·Journal of Neuro-oncology·Isabelle M Germano, Emanuela Binello
Nov 28, 2020·Advanced Biosystems·Lili ZhouFangfang Zhou
Feb 4, 2021·STAR Protocols·Katharina M EymeChristian E Badr
Mar 30, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wenli ChenXiaochun Zhang

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