Preventing herpes zoster through vaccination: New developments

Cleveland Clinic Journal of Medicine
Phuc LeMichael B Rothberg

Abstract

Herpes zoster (HZ) affects 1 million Americans every year. The disease burden is higher in immunocompromised patients. The live-attenuated HZ vaccine is effective in preventing HZ and postherpetic neuralgia and has been recommended for immunocompetent adults age 60 and older. However, because protection wanes by 10 years, a booster may be necessary. In 2015, an adjuvanted subunit HZ vaccine was shown to reduce incidence by 97%, even in the elderly, but long-term data on vaccine protection are not available. Clinical trials are under way to investigate a safe and effective vaccine for immunocompromised patients.

Citations

May 1, 2018·Current Opinion in Ophthalmology·Saujanya Vadoothker, Bennie H Jeng
Apr 15, 2020·Minerva medica·Silvia CocchioVincenzo Baldo
Mar 28, 2018·MMW Fortschritte der Medizin·Uwe Wollina
Jul 22, 2018·Expert Review of Vaccines·Nicolas LecrenierAlain Brecx

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