Preventing intellectual disability during pregnancy: what are the potentially high yield targets?

Journal of Perinatal Medicine
Yinding WangJames W Hardin

Abstract

To identify risk factors among children with unknown cause intellectual disability (ID) and to estimate the population-attributable risk (PAR) associated with these factors. This was a retrospective cohort study of maternal and child pairs born between 2004 and 2010 in South Carolina, and information was obtained from Medicaid billing records, birth certificates, and other administrative data. The data included 123,922 children and logistic generalized estimating equations (GEE) regression models were used to estimate the association of maternal risk factors and ID. We estimated models with and without birth weight as a covariate, since low birth weight is known to be a mediator of the association between some risk factors and ID in children. The prevalence of ID in the children was 3.85% and the associations between risk factors and ID were similar for female and male children. We found that the odds of having ID were increased if a child's mother had a diagnosis of major depression; for male children, the odds ratio (OR) was 1.34 (95% confidence interval [CI] 1.14-1.59, PAR 2.17%); and for females, the OR was 1.59 (95% CI 1.30-1.95, PAR 4.70%). The odds of having ID were also increased for children of women with bipolar disor...Continue Reading

References

Mar 4, 2000·Developmental Medicine and Child Neurology·P Strømme
Sep 7, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Helen Leonard, Xingyan Wen
Mar 2, 2006·Journal of Intellectual Disability Research : JIDR·C P HemmingsN Bouras
Nov 4, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Vera A MorganAssen Jablensky
Jan 24, 2009·Epilepsy & Behavior : E&B·Peter MartinBarbara Schäuble
Dec 1, 2009·Annals of Epidemiology·Joshua R MannLi Zhou
Jun 29, 2010·Depression and Anxiety·Salvatore Gentile
Sep 18, 2010·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Margaret Irene GriffithSuzanne McDermott
Jan 18, 2011·Research in Developmental Disabilities·Pallab K MaulikShekhar Saxena
May 25, 2011·Pediatrics·Coleen A BoyleMichael D Kogan
Sep 16, 2011·Journal of Intellectual Disability Research : JIDR·K A Peebles, T J Price
Jan 14, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Vera A MorganAssen V Jablensky
Apr 10, 2012·American Journal of Human Genetics·Herbert A LubsCharles E Schwartz
Jul 17, 2012·Maternal and Child Health Journal·Joshua R MannJames W Hardin
Sep 19, 2012·Developmental Medicine and Child Neurology·Joshua R MannJames W Hardin
Nov 30, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·J R MannZ Zhang
Jan 4, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Olaoluwa OkusagaTeodor T Postolache
Aug 1, 2013·Expert Review of Neurotherapeutics·Bianca PfaffensellerFlávio Kapczinski
Feb 21, 2014·Pharmacological Reports : PR·Marcin SiwekGabriel Nowak
Aug 27, 2014·Pediatrics·John B MoeschlerUNKNOWN Committee on Genetics

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.