Preventing intraperitoneal adhesions with atorvastatin and sodium hyaluronate/carboxymethylcellulose: a comparative study in rats

American Journal of Surgery
M LalountasA K Sakantamis

Abstract

The aim of this study was to compare the effectiveness of atorvastatin with the sodium hyaluronate/carboxymethylcellulose (HA/CMC, Seprafilm; Genzyme; Genzyme Biosurgery Corporation, Cambridge, MA) in preventing postoperative intraperitoneal adhesion formation in rats. Sixty Wistar rats underwent a laparotomy, and adhesions A were induced by cecal abrasion. The animals were divided into 4 groups: group 1, control A; group 2, (A + atorvastatin); group 3, (A + HA/CMC), and group 4, (A + atorvastatin + HA/CMC). The atorvastatin (groups 2 and 4) and HA/CMC (groups 3 and 4) were administered intraperitoneally before the abdominal wall was closed. After 14 days, adhesions were classified by 2 independent surgeons. The adhesion scores (mean +/- standard deviation) for groups 1, 2, 3, and 4 were 2.93 +/- .59, 1.85 +/- 1.07, 1.80 +/- .86, and 1.93 +/- .70, respectively. The differences in adhesion scores among all 3 preventive groups (groups 2, 3, and 4) were statistically significant when compared with the control group (P = .005, P = .002, and P = .009, respectively). These data suggest that atorvastatin, administered intraperitoneally, is as effective as HA/CMC without an expectable additive effect in preventing postoperative adhesio...Continue Reading

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Citations

Feb 3, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Christoph BrochhausenC James Kirkpatrick
Aug 29, 2012·International Journal of Medical Sciences·Xiaohong DuGuohui Liu
Oct 24, 2013·International Journal of Medical Sciences·D ÅkerbergB Tingstedt
Mar 5, 2014·Langenbeck's Archives of Surgery·Bernhard W RenzReinhold A Lang
Nov 15, 2011·The Journal of Surgical Research·Peyman DinarvandMasoud Soleimani
Feb 11, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Nasuh U DoganCavidan Gulerman
Jan 17, 2012·The British Journal of Surgery·M LalountasA K Sakantamis
Apr 18, 2013·The British Journal of Surgery·A A ChaturvediH van Goor
Nov 10, 2015·BioMed Research International·Timothy BowenThomas Sitter
Aug 16, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E Kıyak CaglayanB Güngör
Aug 30, 2014·The Journal of Surgical Research·Tae Han KimHyun Kang
Dec 3, 2014·The Spine Journal : Official Journal of the North American Spine Society·Bora GürerAysun Gökçe
Nov 23, 2013·Journal of the Korean Surgical Society·Dong Sik BaeYeo-Kyu Youn
Feb 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fatemeh SarviPeggy P Y Chan

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