Preventing microalbuminuria in patients with diabetes: rationale and design of the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study

Journal of Hypertension
Hermann HallerAndrzej Januszewicz

Abstract

Diabetic nephropathy has developed into a worldwide epidemic and is responsible for the majority of end-stage renal disease in most countries. Antihypertensive treatment slows the progression of the disease. In addition, blockade of the renin-angiotensin system reduces the degree of albuminuria and angiotensin II receptor blockers (ARBs) have been shown to delay the progression from microalbuminuria to overt proteinuria in patients with diabetes. However, few studies have examined whether the initial stage of diabetic nephropathy (i.e. the development of microalbuminuria) in patients with type 2 diabetes can be slowed or prevented by ARB treatment. The Randomised Olmesartan And Diabetes MicroAlbuminuria Prevention (ROADMAP) study is a placebo-controlled, multicentre, double-blind, parallel group study investigating the effect of the ARB, olmesartan medoxomil, on the incidence of microalbuminuria. A total of 4400 type 2 diabetes patients with normoalbuminuria will be randomized to treatment with 40 mg of olmesartan medoxomil once daily or placebo. Goal blood pressure will be 130/80 mmHg. The primary endpoint of the study is the occurrence of microalbuminuria. In ROADMAP, we will also assess as secondary endpoints the effects of ...Continue Reading

References

Sep 21, 2000·Kidney International. Supplement·D J LeeheyR Singh
May 4, 2001·The American Journal of Cardiology·J M Neutel
Jul 14, 2001·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·K J BallK O Stumpe
Sep 22, 2001·The New England Journal of Medicine·E J LewisUNKNOWN Collaborative Study Group
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Sep 22, 2001·The New England Journal of Medicine·H H ParvingUNKNOWN Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group
Jun 7, 2002·Lancet·Lars H Lindholm
Jun 22, 2002·Drugs·Gregory T Warner, Blair Jarvis
Aug 7, 2002·Circulation·Giancarlo VibertiUNKNOWN MicroAlbuminuria Reduction With VALsartan (MARVAL) Study Investigators
Dec 31, 2002·The Annals of Pharmacotherapy·Stephanie F Gardner, Amy M Franks
Feb 22, 2003·Journal of the American Society of Nephrology : JASN·Johannes F E MannSalim Yusuf
Sep 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Solfrid RomundstadHanne Ellekjaer
Aug 18, 2004·Circulation·Danilo FliserUNKNOWN EUropean Trial on Olmesartan and Pravastatin in Inflammation and Atherosclerosis (EUTOPIA) Investigators
Nov 2, 2004·The New England Journal of Medicine·Anthony H BarnettUNKNOWN Diabetics Exposed to Telmisartan and Enalapril Study Group
Nov 2, 2004·The New England Journal of Medicine·Piero RuggenentiUNKNOWN Bergamo Nephrologic Diabetes Complications Trial (BENEDICT) Investigators
Nov 27, 2004·BMJ : British Medical Journal·Subodh Verma, Marty Strauss
Feb 18, 2005·Journal of the American Society of Nephrology : JASN·Danilo FliserHermann Haller
Sep 2, 2005·Journal of the American Society of Nephrology : JASN·Giovanni F M StrippoliJonathan C Craig

❮ Previous
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Citations

Aug 10, 2007·Current Hypertension Reports·Joseph L Izzo
Aug 10, 2010·Current Hypertension Reports·Giovanna LeonciniRoberto Pontremoli
Aug 8, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tadashi Sofue, Hideyasu Kiyomoto
Mar 11, 2011·The New England Journal of Medicine·Hermann HallerUNKNOWN ROADMAP Trial Investigators
Jun 24, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Harald Mischak, Peter Rossing
Jun 13, 2009·Diabetes, Obesity & Metabolism·Rigas Kalaitzidis, George Bakris
Jun 26, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daisuke KadowakiMasaki Otagiri
Oct 30, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ikuo SaitoTakao Saruta
Jan 1, 2010·Integrated Blood Pressure Control·Eduardo Pimenta, Suzanne Oparil
Feb 28, 2007·Vascular Health and Risk Management·Hans R Brunner
May 14, 2009·Vascular Health and Risk Management·Alessandra Del FiorentinoRoberto Pedrinelli
Sep 23, 2010·Vascular Health and Risk Management·Carlos M Ferrario, Ronald D Smith
Dec 31, 2010·Vascular Health and Risk Management·Maria Leonarda De Rosa
Jul 1, 2008·Future Cardiology·Christoph Schindler, Carlos M Ferrario
Jan 23, 2014·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·W Kleophas, F Dellanna
Mar 26, 2009·Der Internist·I Quack, L C Rump
Sep 1, 2008·Expert Review of Clinical Pharmacology·Mark Greathouse
Aug 20, 2009·Expert Opinion on Drug Metabolism & Toxicology·Maurizio DestroFrancesca Cagnoni
Mar 28, 2008·Current Medical Research and Opinion·Luis M Ruilope
Oct 20, 2009·Current Medical Research and Opinion·Francesco LocatelliTevfik Ecder
Mar 23, 2010·Current Medical Research and Opinion·Milan GuptaAldo P Maggioni
May 24, 2011·International Journal of Nephrology·José A García-Donaire, Luis M Ruilope
Dec 12, 2012·Mayo Clinic Proceedings·Jan Menne, Hermann Haller
Apr 24, 2015·Clinical and Experimental Nephrology·Daisuke KadowakiMasaki Otagiri
Oct 22, 2008·Cardiology Clinics·Usman Javed, Prakash C Deedwania
Sep 9, 2006·Endocrinology and Metabolism Clinics of North America·Karin Jandeleit-Dahm, Mark E Cooper
Nov 3, 2009·The Journal of Clinical Hypertension·Rigas Kalaitzidis, George Bakris
Jul 2, 2010·The Journal of Clinical Hypertension·Luis RuilopeJames Sowers
Jun 13, 2015·Annales de cardiologie et d'angéiologie·M Ould Sidi Mohamed, P Colardelle
May 1, 2016·Annales de cardiologie et d'angéiologie·M Ould Sidi Mohamed, P Colardelle
Nov 27, 2009·Postgraduate Medicine·Shawna D Nesbitt
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Jicheng LvGiovanni F M Strippoli
Dec 12, 2007·Hypertension·Lizzy M BrewsterGert A van Montfrans
Jul 17, 2010·Journal of Hypertension·Jan MenneHermann Haller
Jan 22, 2008·Journal of Neurology·Lizzy M BrewsterMarianne de Visser
Dec 14, 2007·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·David H G Smith
May 5, 2010·Nature Reviews. Nephrology·Piero RuggenentiGiuseppe Remuzzi

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