Preventing post-exercise nocturnal hypoglycemia in children with type 1 diabetes.

The Journal of Pediatrics
Craig E TaplinRosanna Fiallo-Scharer

Abstract

To determine the effects of reducing overnight basal insulin or a bedtime dose of terbutaline on nocturnal blood glucose (BG) nadir and hypoglycemia after exercise in children with type 1 diabetes mellitus. Sixteen youth (mean age 13.3 years) on insulin pumps were studied overnight on 3 occasions after a 60-minute exercise session with BG measurements every 30 minutes. Admissions were randomized to bedtime treatment with oral terbutaline 2.5 mg, 20% basal rate insulin reduction for 6 hours, or no treatment. Mean overnight nadir BG was 188 mg/dL after terbutaline and 172 mg/dL with basal rate reduction compared with 127 mg/dL on the control night (P = .002 and .042, respectively). Terbutaline eliminated nocturnal hypoglycemia but resulted in significantly more hyperglycemia (≥250 mg/dL) when compared with the control visit (P < .0001). The basal rate reduction resulted in fewer BG readings <80 and <70 mg/dL but more readings ≥250 mg/dL when compared with the control visit. A basal insulin rate reduction was safe and effective in raising post-exercise nocturnal BG nadir and in reducing hypoglycemia in children with type 1 diabetes mellitus. Although effective at preventing hypoglycemia, a 2.5-mg dose of terbutaline was associated...Continue Reading

References

Apr 28, 2005·Diabetes Care·UNKNOWN Workgroup on Hypoglycemia, American Diabetes Association
Oct 18, 2005·The Journal of Pediatrics·Eva TsalikianUNKNOWN Diabetes Research In Children Network Direcnet Study Group
Nov 23, 2005·Archives of Disease in Childhood·J I Wolfsdorf
Feb 24, 2006·Pediatric Diabetes·M C Riddell, K E Iscoe
Feb 24, 2006·The Journal of Clinical Endocrinology and Metabolism·Bharathi RajuPhilip E Cryer
Jun 7, 2006·Archives of Pediatrics & Adolescent Medicine·Antje HerbstReinhard W Holl
Aug 17, 2006·Pediatric Diabetes·Linda A Gonder-FrederickWilliam L Clarke
May 1, 2007·Diabetes Care·Antje HerbstUNKNOWN DPV Initiative of the German Working Group for Pediatric Diabetology Germany
Jul 31, 2007·Pediatric Diabetes·UNKNOWN Diabetes Research in Children Network (DirecNet) Study Group
Oct 13, 2007·Diabetes Technology & Therapeutics·Laura ScrimgeourH Peter Chase
Aug 12, 2008·Diabetes Care·Anne-Sophie BrazeauHortensia Mircescu
Aug 13, 2008·Diabetes Care·Bruce BuckinghamFergus Cameron
Sep 11, 2008·Diabetes Care·Benjamin A CooperbergPhilip E Cryer
Sep 17, 2009·Pediatric Diabetes·Kenneth RobertsonMichael C Riddell
Oct 24, 2009·Diabetes Technology & Therapeutics·Bruce BuckinghamH Peter Chase

❮ Previous
Next ❯

Citations

Sep 22, 2011·Diabetes Technology & Therapeutics·Jaime M Realsen, H Peter Chase
Jun 22, 2012·International Journal of Pediatric Endocrinology·Kimberly E LeheckaRubina A Heptulla
Jan 25, 2014·Paediatric Drugs·Faisal S Malik, Craig E Taplin
Feb 3, 2016·Diabetes Technology & Therapeutics·Aoibhe M PasiekaMichael C Riddell
May 16, 2014·Canadian Journal of Diabetes·Ronald J SigalMichael C Riddell
Jul 14, 2012·Advances in Pediatrics·Shideh Majidi, David M Maahs
Sep 21, 2010·The Journal of Pediatrics·Lori Laffel
Jun 18, 2014·Diabetes Care·Jane L ChiangUNKNOWN Type 1 Diabetes Sourcebook Authors
Mar 11, 2015·Pediatric Diabetes·Jacklyn A PivovarovMichael C Riddell
Apr 5, 2015·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Manuel Gargallo-FernándezUNKNOWN en representación del Grupo de Trabajo de Diabetes Mellitus de la Sociedad Española de Endocrinología y Nutrición (SEEN)
Aug 16, 2016·Current Diabetes Reports·Dayna E McGill, Lynne L Levitsky
Feb 14, 2017·Diabetes Technology & Therapeutics·Aoibhe M Pasieka, Michael C Riddell
Jan 28, 2017·The Lancet. Diabetes & Endocrinology·Michael C RiddellLori M Laffel
Jan 31, 2017·Diabetes Technology & Therapeutics·Bruce W BodeNan Vint
Jan 10, 2017·Current Sports Medicine Reports·Jane E Yardley, Sheri R Colberg
Apr 21, 2017·Diabetes Technology & Therapeutics·Jordan E Pinsker, Eyal Dassau
May 19, 2017·Diabetes Technology & Therapeutics·Lenka PetruzelkovaBarbora Obermannova
Jun 16, 2011·The Physician and Sportsmedicine·Lisa ChuMichael C Riddell
Dec 1, 2019·Experimental Physiology·E J CockcroftR C Andrews
Dec 22, 2019·Diabetes Care·UNKNOWN American Diabetes Association
Mar 16, 2017·Acta Diabetologica·Roberto CodellaLivio Luzi
Dec 19, 2018·Diabetes Care·UNKNOWN American Diabetes Association
Feb 23, 2011·Expert Review of Endocrinology & Metabolism·Lisa M YounkStephen N Davis
Jul 2, 2019·Frontiers in Endocrinology·Tarini ChettyElizabeth Ann Davis
Oct 28, 2020·Current Obesity Reports·Dessi P ZaharievaDavid M Maahs
Aug 28, 2020·The Journal of Clinical Endocrinology and Metabolism·Clara ViñalsMarga Giménez
Jul 8, 2020·International Journal of Sports Medicine·Mikołaj KamińskiDorota Zozulinska-Ziolkiewicz
Dec 11, 2020·Diabetes Care·UNKNOWN American Diabetes Association
May 18, 2021·World Journal of Diabetes·Maja Cigrovski BerkovicVjekoslav Cigrovski
Jul 1, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Nuria VilarrasaAlbert Lecube

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.