Preventing postoperative abdominal adhesions in a rat model with PEG-PCL-PEG hydrogel.

International Journal of Nanomedicine
Bing YangZhi Yong Qian

Abstract

Poly (ethylene glycol)-poly (ɛ-caprolactone)-poly (ethylene glycol) (PEG-PCL-PEG, PECE) hydrogel has been demonstrated to be biocompatible and thermosensitive. In this study, its potential efficacy and mechanisms of preventing postsurgical abdominal adhesions were investigated. PECE hydrogel was transformed into gel state from sol state in less than 20 seconds at 37°C. None of the animals treated with the hydrogel (n = 15) developed adhesions. In contrast, all untreated animals (n = 15) had adhesions that could only be separated by sharp dissection (P < 0.001). The hydrogel adhered to the peritoneal wounds, gradually disappeared from the wounds within 7 days, and transformed into viscous fluid, being completely absorbed within 12 days. The parietal and visceral peritoneum were remesothelialized in about 5 and 9 days, respectively. The hydrogel prevented the formation of fibrinous adhesion and the invasion of fibroblasts. Also, along with the hydrogel degradation, a temporary inflammatory cell barrier was formed which could effectively delay the invasion of fibroblasts during the critical period of mesothelial regeneration. The results suggested that PECE hydrogel could effectively prevent postsurgical intra-abdominal adhesions,...Continue Reading

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Citations

Jul 4, 2013·Journal of Materials Science. Materials in Medicine·Zengjuan ZhengHeidi M Mansour
Jul 26, 2013·International Journal of Nanomedicine·Xiang GaoNing Huang
Feb 14, 2014·International Journal of Nanomedicine·Qinjie WuChangyang Gong
Oct 5, 2013·International Journal of Surgery·Elias ShahramMohammad Reza Naimi-Jamal
Dec 7, 2014·Journal de gynécologie, obstétrique et biologie de la reproduction·S WarembourgV Letouzey
Feb 2, 2015·International Journal of Surgery·Turan YildizFatma Husniye Dilek

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Methods Mentioned

BETA
rheometry
scanning electron microscopy
light microscopy
dissection

Software Mentioned

SPSS

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