Preventing transfer of infectious agents

International Journal of Surgery
Joachim Denner, Nicolas J Mueller

Abstract

Xenotransplantation using pig cells, tissues and organs may be associated with the transfer of porcine infectious agents, which may infect the human recipient and in the worst case induce a disease (zoonosis). To prevent this, a broad screening program of the donor animals for putative zoonotic microorganisms, including bacteria, viruses, fungi and others, using sensitive and specific detection methods has to be performed. As long as it is still unknown, which microorganism represents a real risk for the recipient, experience from allotransplantation should be brought in. Due to the fact that pigs can be screened long before the date of transplantation, xenotransplantation will become eventually safer compared with allotransplantation. Screening and selection of animals free of potential zoonotic microorganisms, Caesarean section, vaccination and/or treatment with chemotherapeutics are the strategies of choice to obtain donor animals not transmitting microorganisms. In the case of porcine endogenous retroviruses (PERVs) which are integrated in the genome of all pigs and which cannot be eliminated this way, selection of animals with low virus expression and generation of genetically modified pigs suppressing PERV expressions may...Continue Reading

References

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Citations

Jul 22, 2016·Xenotransplantation·Vladimir A MorozovJoachim Denner
Aug 9, 2016·Journal of Immunological Methods·Elena PlotzkiJoachim Denner
Apr 21, 2017·Viruses·Joachim Denner, Annette Mankertz
Dec 12, 2017·British Medical Bulletin·D K C CooperA J Tector
Dec 15, 2017·Journal of Immunology Research·Christopher G A McGregor, Guerard W Byrne
Apr 12, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P J Cowan, A J Tector
Jun 19, 2018·Xenotransplantation·Linda ScobiePierre Gianello
Dec 13, 2018·ILAR Journal·Jeffrey L PlattJorge A Piedrahita
Apr 17, 2019·Contemporary Nurse·Deborah SpenceStephen Neville
Sep 7, 2017·Virology Journal·Joachim Denner
Jul 19, 2016·Transplantation·David K C CooperBurcin Ekser
Oct 10, 2018·Current Opinion in Organ Transplantation·Anoma Nellore
Jul 25, 2017·Transplantation·David K C CooperDavid H Sachs
Sep 20, 2018·Current Diabetes Reports·Elisabeth KemterEckhard Wolf
Jul 5, 2018·Frontiers in Microbiology·Jun HuXianghua Yan
Feb 7, 2021·Archives of Virology·Joachim Denner
Sep 14, 2017·Current Opinion in Organ Transplantation·Burcin EkserDavid K C Cooper

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Methods Mentioned

BETA
PCR
PCRs
transgenic

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