PMID: 11926575Apr 3, 2002Paper

Prevention and chemoprevention of colorectal neoplasms

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
DeLeonM Ponz

Abstract

Main purpose of the review is to analyse the impact of the current approaches for colorectal cancer prevention, including chemoprevention. Available evidence does not support the contention that a more appropriate diet can be of great help in the prevention of these neoplasms, either because the scientific evidence is poor and highly controversial, or because changes in diet are difficult to implement, at least in many Western countries. Similarly, a preventive approach based on the modification of lifestyle remains improbable, either in the short --or in the long period of time. Secondary prevention--i.e., the systematic removal of adenomatous polyps--can hardly be applied in the general population, with the exception of individuals at risk because members of families with Adenomatosis coli or Lynch syndrome, or affected by inflammatory bowel diseases. Finally, chemoprevention (i.e., the attempt to prevent tumour development through the administration of drugs or natural compounds that interfere with various phases of carcinogenesis) is still in its infancy Though attractive, this approach requires well-designed studies which should be carried out for years before being evaluated and interpreted; so far most of these investiga...Continue Reading

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Citations

Jun 30, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Uri LadabaumA Mark Fendrick
Jan 19, 2012·Journal of Cancer Epidemiology·David Omoareghan Irabor
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Feb 9, 2008·Carcinogenesis·Mark J SinnamonLynn M Matrisian
Aug 14, 2002·World Journal of Gastroenterology : WJG·Lian-Xin LiuDa-Xun Piao

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