Prevention and management of gastroesophageal varices in cirrhosis.

International Journal of Hepatology
Yen-I Chen, Peter Ghali

Abstract

Variceal hemorrhage is one of the major complications of liver cirrhosis associated with significant mortality and morbidity. Its management has evolved over the past decade and has substantially reduced the rate of first and recurrent bleeding while decreasing mortality. In general, treatment of esophageal varices can be divided into three categories: primary prophylaxis (prevention of first episode of bleeding), management of acute bleeding, and secondary prophylaxis (prevention of recurrent hemorrhage). The goal of this paper is to describe the current evidence behind the management of esophageal varices. We will discuss indications for primary prophylaxis and the different modes of therapy, pharmacological and interventional treatment in acute bleeding, and therapeutic options in preventing recurrent bleeding. The indications for TIPS will also be reviewed including its possible benefits in acute variceal hemorrhage.

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Citations

Oct 29, 2013·Best Practice & Research. Clinical Gastroenterology·Iyad Khamaysi, Ian M Gralnek
Dec 11, 2013·Cardiovascular and Interventional Radiology·Atsushi JogoYukio Miki
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May 24, 2019·Internal Medicine·Atsushi JogoYukio Miki
Mar 13, 2021·Drugs·Saleh A Alqahtani, Sunguk Jang
Jan 5, 2021·Journal of Pediatric Gastroenterology and Nutrition·Monique T BarakatRoberto Gugig

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