PMID: 8589922Oct 1, 1995Paper

Prevention and reversal of superantigen-induced anergy by contact allergen exposure

Experimental Dermatology
J SalogaJ Knop

Abstract

The superantigen Staphylococcal enterotoxin B (SEB) and the contact allergen 2,4-dinitrofluorbenzene (DNFB) both react with V beta 8+ T-cells delivering distinct signals. Pre-treatment with DNFB painted onto the same skin site where SEB was to be injected, prevented the induction of anergy in V beta + T-cells that was otherwise induced after SEB had been injected intradermally over a period of 2 weeks. Application of the irritant sodium dodecyl sulfate (SDS) instead of DNFB did not exert this effect. Application of DNFB at a site distant from the site where SEB was injected resulted in a much weaker inhibitory influence on the induction of anergy by SEB. Established anergy of V beta 8+ T-cells (proliferative non-responsiveness to SEB in vitro that could be overcome by addition of exogenous interleukin 2 (IL-2)) could be largely reversed by repeated cutaneous exposure to DNFB painted to the site where SEB had been injected before. The moderate decrease of V beta 8+ T-cells normally induced by SEB-treatment was also partially prevented by DNFB pre-treatment. The data indicate the importance of the sequence of signals delivered to T cells and the plasticity of the responsiveness of this cell type.

References

Sep 3, 1992·Nature·M RöckenE M Shevach
May 11, 1990·Science·P Marrack, J Kappler
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y W ChoiJ Kappler
Mar 10, 1989·Cell·J M White, D R Littman
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J E McCormackP Marrack

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Citations

Apr 1, 1996·Experimental Dermatology·J SalogaJ Knop
Oct 9, 2003·Current Allergy and Asthma Reports·Claus BachertPaul Van Cauwenberge

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