Prevention and therapy of osteoporosis: the roles of plain vitamin D and alfacalcidol

Rheumatology International
Johann D Ringe, Erich Schacht

Abstract

Severe vitamin D deficiency was identified only in the first decades of the last century as the most common aetiology of rickets in children and osteomalacia in adults. It was later shown that vitamin D is not, as had been supposed, the biologically active principle for healing bone disease but must be hydroxylated in the liver and then finally in the kidney to become 1alpha,25-dihydroxy-cholecalciferol, a biologically highly active renal hormone. This study reviews the various principles, mechanisms, and approaches to the treatment of different forms of osteoporosis using vitamin D, alfacalcidol, and calcitriol therapy regimens.

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Citations

Jun 4, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Laurent DukasHannes B Stähelin
Jan 14, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C-L ShenJ-S Wang
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Feb 24, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alicia BasEscolastico Aguilera-Tejero
Oct 6, 2005·Biological & Pharmaceutical Bulletin·Fang XieMan-Sau Wong
Dec 29, 2020·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Eiji ItoiMasataka Shiraki

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