Prevention and therapy of viral infections in patients with solid organ transplantation.

Enfermedades infecciosas y microbiología clínica
Jose Tiago SilvaJosé María Aguado

Abstract

Solid organ transplantation (SOT) is the best treatment option for end-stage organ disease. The number of SOT procedures has been steadily increasing worldwide during the past decades. This trend has been accompanied by the continuous incorporation of new antimicrobial drugs and by the refinement of strategies aimed at minimizing the risk of opportunistic infection. Nonetheless, viral infections, which can occur at any stage of the post-transplant period, remain a clinical challenge that negatively impacts both patient and graft outcomes. This review offers an overview of the most relevant viral infections in the SOT population, with a focus on herpesviruses (cytomegalovirus, Epstein-Barr virus, varicella-zoster virus, and herpes simplex virus 1 and 2) and polyomaviruses (human BK polyomavirus). In addition, the currently recommended prophylactic and treatment approaches are summarized, as well as the new antiviral agents in different phases of clinical development.

References

Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C ArnoldR Williams
Apr 3, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M R Zamora
Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·David WeillDavid C McGiffin
Nov 12, 1964·The New England Journal of Medicine·R B HILLD RIFKIND
Jan 2, 2004·The New England Journal of Medicine·Lawrence CoreyUNKNOWN Valacyclovir HSV Transmission Study Group
Jun 7, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J GavaldaUNKNOWN RESITRA (Spanish Network for Research on Infection in Transplantation)
Apr 28, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S WalkerR Khanna
Jan 12, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Oriol ManuelAtul Humar
Sep 16, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Rik A BrooimansMichael Keeney
Jan 31, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·X L PangUNKNOWN Canadian Society of Transplantation
Sep 16, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Núria Fernàndez-SabéJordi Carratalà
Apr 23, 2010·British Journal of Haematology·Anne ParkerUNKNOWN Haemato-oncology Task Force of the British Committee for Standards in Haematology and British Transplantation Society
May 29, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Steven GabardiAnil Chandraker
Jul 10, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Janet H KimJanice M Y Brown
Jul 20, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S A PergamB A Young
Sep 6, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D J WinstonUNKNOWN 1263-301 Clinical Study Group
Sep 20, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adrian EgliDeepali Kumar
Dec 1, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Oriol ManuelAtul Humar
Jan 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S CantisánJ Torre-Cisneros
Feb 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A Fishman
Feb 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Green, M G Michaels
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H H HirschUNKNOWN AST Infectious Diseases Community of Practice
May 29, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·O BestardJ M Cruzado
Oct 3, 2013·Cold Spring Harbor Perspectives in Medicine·Jay A Fishman
Nov 1, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Spencer T MartinDemetra Tsapepas
Jan 8, 2014·Infection & chemotherapy·Poornima Ramanan, Raymund R Razonable
Jan 31, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R San-JuanP Meylan
Feb 1, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Belinda T LeeAnil Chandraker
Feb 18, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J A Fishman
Sep 11, 2014·The Journal of Pathology·Paul GriffithsMatt Reeves
Nov 16, 2014·JAMA : the Journal of the American Medical Association·Greg A KnollJohn S Gill
Nov 27, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Tomas ReischigMirko Bouda
Dec 17, 2014·Clinical & Translational Immunology·Mario Fernández-RuizAtul Humar
Jan 30, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M A SchnitzlerB L Kasiske
Feb 18, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R San-JuanUNKNOWN ESGICH PTLD Survey Study Group, on behalf of the European Study Group of Infections in Compromised Hosts (ESGICH) from the E
Mar 25, 2015·Antimicrobial Agents and Chemotherapy·Garth D TyldenChristine Hanssen Rinaldo
Apr 14, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Mario Fernández-RuizUNKNOWN OPERA Study Group
Apr 15, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J RossignolF Morschhauser

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