Prevention and treatment of Lewis rat experimental allergic encephalomyelitis with a monoclonal antibody to the T cell receptor V beta 8.2 segment

European Journal of Immunology
H ImrichT Hünig

Abstract

The predominance of T cell receptor (TCR) V beta 8.2 utilization by encephalitogenic T cells induced in Lewis rats by immunization with myelin basic protein (MBP) is controversial. Thus, both an almost exclusive usage of V beta 8.2 [Burns, F. R., Li, X., Shen, N., Offner, H., Chou, Y. K., Vandenbark, A. A. and Heber-Katz, E., J. Exp. Med. 1989, 169: 27; Chluba, J., Steeg, C., Becker, A., Wekerle, H. and Epplen, J. T., Eur. J. Immunol. 1989. 19: 279] and a quite diverse V beta composition of CD4 T cells causing experimental autoimmune encephalomyelitis (EAE) [Sun, D., Gold, P. D., Smith, L., Brostoff, S. and Coleclough, C., Eur. J. Immunol, 1992. 22: 591; Sun, D., Le, J. and Coleclough, C., Eur. J. Immunol. 1993. 23: 494] have been reported. Using a recently developed monoclonal antibody (mAb) specific for TCR V beta 8.2, we show that postnatal treatment effectively eliminates V beta 8.2-bearing cells and prevents MBP-induced EAE in the majority of Lewis rats. Moreover, treatment of adult Lewis rats with V beta 8.2-specific mAb as late as on day 12 after MBP immunization suppressed the development of neurological symptoms. Thus, V beta 8.2-bearing cells do play a decisive role in Lewis rat EAE, and suppression of the small (5%) ...Continue Reading

References

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Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A Ben-NunM A Bach
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Jun 1, 1994·European Journal of Immunology·D SunR H Swanborg

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Citations

May 29, 1998·European Journal of Immunology·M TakeuchiO Taguchi
May 29, 1998·European Journal of Immunology·Y MatsumotoN Tanuma
Feb 12, 1997·Journal of the Neurological Sciences·A Khalili-ShiraziJ S Lanchbury
May 1, 1997·The European Journal of Neuroscience·L SchnellM E Schwab
Feb 13, 2001·Journal of Neuroimmunology·S MuhallabA Svenningsson
Mar 15, 2014·Autoimmunity·Sylwia WrotekWiesław Kozak
Jan 1, 1996·International Reviews of Immunology·O J FinnD K Bishop
Mar 4, 2000·International Immunology·K M DrescherM Rodriguez
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Valérie DuplanAbdelhadi Saoudi

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