Abstract
Though 40 years have passed since its discovery, respiratory syncytial virus (RSV), one of the most ubiquitous viruses known, continues to evade most of our efforts to prevent or treat the clinical disease it causes. Long recognised as the most common cause of lower respiratory tract infections in virtually all children in the first 2 years of life, it has been increasingly recognised as a cause of more serious disease in several 'high risk' populations. These populations include infants with cardiac or pulmonary disease and infants and adults with immunodeficiencies, particularly those undergoing bone marrow transplantation. Early attempts to immunise children with a simple formalin-inactivated vaccine led to severe disease in vaccinated children who subsequently were infected with RSV from the community. Other vaccine constructs have failed for a variety of reasons, although surface glycoprotein subunit vaccines may hold promise. For years, ribavirin, a synthetic nucleoside analogue administered by constant aerosol, has been felt by many to lead to more rapid improvement in clinical disease caused by RSV, but it is still unclear whether its benefits are truly significant. An intravenous immunoglobulin product prepared from do...Continue Reading
Citations
Nov 30, 2000·Current Infectious Disease Reports·M G Ottolini
Feb 26, 2004·Bioorganic & Medicinal Chemistry Letters·Kuo-Long YuNicholas A Meanwell
Nov 25, 2003·Il Farmaco·N A SantagatiG Ronsisvalle
Jul 9, 2004·The Journal of Pediatrics·Yves SznajerBaruch Joseph Toledano
Oct 1, 2003·Antiviral Research·Philip R WydePedro A Piedra
Nov 7, 1998·Antiviral Research·P R Wyde
Jun 12, 2003·Bioorganic & Medicinal Chemistry Letters·Kuo Long YuNicholas A Meanwell
May 29, 2000·Drug Discovery Today·N A Meanwell, M Krystal
Oct 24, 2001·Pediatric Emergency Care·A AroraJ Singer
Apr 19, 2000·Antimicrobial Agents and Chemotherapy·P R WydeB E Gilbert
Jun 19, 2002·Antimicrobial Agents and Chemotherapy·Martin G OttoliniGregory A Prince
Mar 11, 2000·Pharmacotherapy·G C Wood, B A Boucher
Aug 5, 2000·The Pediatric Infectious Disease Journal·X Carbonell-EstranyM Zapatero
Jun 7, 2008·Pediatrics International : Official Journal of the Japan Pediatric Society·Yamini DuraniMagdy W Attia
Dec 22, 2005·Bioorganic & Medicinal Chemistry Letters·Kuo-Long YuNicholas A Meanwell
Jul 20, 1999·The Annals of Pharmacotherapy·K D Dominguez, R C Mercier
Oct 9, 2009·Journal of Medical Economics·Mark NuijtenWolfgang Wittenberg
Mar 9, 2000·Hospital Medicine·A B Russell
Nov 13, 2004·Antiviral Chemistry & Chemotherapy·Donald F SmeeRobert W Sidwell
Nov 11, 2009·Journal of Medical Economics·Derrick Y TamKrista L Lanctôt
Aug 31, 2001·Clinical and Diagnostic Laboratory Immunology·V G Hemming
May 1, 2012·International Journal of Cancer. Journal International Du Cancer·Yan ZhanBingjian Lu
Aug 21, 2019·BMJ Open·Junjie LiuYanhua Su
Feb 6, 2017·Cold Spring Harbor Perspectives in Biology·Peter D Kwong
Aug 16, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Philip R. Wyde