Prevention by monovalent haptens of IgE-dependent leucocyte histamine release to muscle relaxants

International Archives of Allergy and Immunology
D A Moneret-VautrinM C Laxenaire

Abstract

The cross-reactivity between muscle relaxants (MRs) is a risk for inducing anaphylaxis in sensitized patients. The preventive use of monovalent haptens (MHs) was studied in 21 cases. Inhibition of the skin reactivity by mixing MRs and MHs was observed, as was the inhibition of leucocyte histamine release to MRs, up to 3 h after infusion of MHs. These results argue for the use of such a protocol, if surgery requires the use of a MR in patients at risk for anaphylaxis.

Citations

Mar 12, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·J-M MalinovskyB Plaud
Jun 1, 2000·Clinical Reviews in Allergy & Immunology·D VervloetM Pradal
Jan 1, 1997·Clinical Reviews in Allergy & Immunology·D A Moneret-Vautrin
Dec 19, 2003·Current Allergy and Asthma Reports·Paul-Michel Mertes, Marie Claire Laxenaire
May 18, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Malcolm M Fisher, Gordon S Doig
Jul 1, 2009·Immunology and Allergy Clinics of North America·P M MertesP Demoly
Jun 21, 2002·European Journal of Anaesthesiology·P M Mertes, M C Laxenaire

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

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