Prevention by morphine of N-methyl-D-aspartic acid-induced penile erection and yawning: involvement of nitric oxide

Brain Research Bulletin
M R MelisA Argiolas

Abstract

The effect of morphine on the increase of NO2- and NO3- concentration in the dialysate obtained with a microdialysis probe implanted in the paraventricular nucleus of the hypothalamus, and penile erection and yawning induced by N-methyl-D-aspartic acid (NMDA) was studied in male rats. NMDA (50 ng) injected in the paraventricular nucleus of the hypothalamus, induced penile erection and yawning and increased NO2- from 1.10 +/- 0.28 microM to 7.30 +/- 1.10 microM and NO3- from 5.05 +/- 0.71 microM to 11.03 +/- 1.61 microM. Morphine (1-10 microg), but not U-69,593 (10 microg), a selective agonist of the kappa opiate receptor subtype, prevented in a dose-dependent manner NMDA-induced increase in NO2- and NO3- concentration when injected in the paraventricular nucleus 15 min before NMDA. Morphine prevention of NMDA-induced NO2- and NO3- increase was related to a concomitant decrease in the number of penile erection and yawning episodes induced by the excitatory amino acid. Morphine effect was not observed in male rats treated with the opiate receptor antagonist naloxone (10 microg) microinjected in the paraventricular nucleus 15 min before morphine. The present results suggest that morphine prevents an NMDA-induced increase in parave...Continue Reading

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Citations

Nov 19, 2009·Journal of Anesthesia·Noboru TodaHiroshi Toda
Jul 16, 2013·Progress in Neurobiology·Antonio Argiolas, Maria Rosaria Melis
Sep 12, 2000·European Journal of Pharmacology·M R MelisA Argiolas
Apr 29, 1998·European Journal of Pharmacology·A Argiolas, M R Melis
Jan 22, 2000·Neuroscience and Biobehavioral Reviews·A Argiolas
Jan 8, 1999·Peptides·G A OlsonA J Kastin
Jun 1, 2010·Behavioural Brain Research·Wendy PortilloRaúl G Paredes
Jan 23, 2010·The Journal of Sexual Medicine·Christian GratzkeChristian G Stief
Apr 3, 2003·The European Journal of Neuroscience·Maria Rosaria MelisAntonio Argiolas
Jan 18, 2003·Sleep Medicine Reviews·G DaquinO Blin
Feb 17, 2018·Pharmaceutical Research·Willem Johan van den BrinkElizabeth Cunera Maria de Lange
Jun 14, 2001·The Urologic Clinics of North America·K E Andersson
Nov 18, 2005·The Urologic Clinics of North America·Muammer KendirciWayne J G Hellstrom

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