Prevention from radiation damage by natural products

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Nicolas FischerThomas Efferth

Abstract

Radiotherapy is a mainstay of cancer treatment since decades. Ionizing radiation (IR) is used for destruction of cancer cells and shrinkage of tumors. However, the increase of radioresistance in cancer cells and radiation toxicity to normal tissues are severe concerns. The exposure to radiation generates intracellular reactive oxygen species (ROS), which leads to DNA damage by lipid peroxidation, removal of thiol groups from cellular and membrane proteins, strand breaks and base alterations. Plants have to deal with radiation-induced damage (UV-light of sun, other natural radiation sources). Therefore, it is worth speculating that radioprotective mechanisms have evolved during evolution of life. We hypothesize that natural products from plants may also protect from radiation damage caused as adverse side effects of cancer radiotherapy. The basis of this systematic review, we searched the relevant literature in the PubMed database. Flavonoids, such as genistein, epigallocatechin-3-gallate, epicatechin, apigenin and silibinin mainly act as antioxidant, free radical scavenging and anti-inflammatory compounds, thus, providing cytoprotection in addition to downregulation of several pro-inflammatory cytokines. Comparable effects have...Continue Reading

Citations

Jan 24, 2020·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Dietmar Kültz
Sep 25, 2019·Archives of Pharmacal Research·Xinyan QuZhe Zhou
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