PMID: 8958935Oct 31, 1996Paper

Prevention of a Th1 disease by a Th1 cytokine: IL-12 and diabetes in NOD mice

Annals of the New York Academy of Sciences
R M O'HaraA Nagelin

Abstract

The effects of interleukin-12 on autoimmune diabetes in nonobese diabetic mice was examined. IL-12 was given, intraperitoneally, to NOD females in two different treatment protocols: three times a week, for 2 weeks beginning at 9 weeks of age and a single weekly injection, for 15 weeks, beginning at 9 weeks of age. A significant decrease in diabetes incidence was observed with multidose/short-term IL-12 treatment. Age of disease onset, however, was unchanged. Weekly administration of IL-12 was more effective in preventing onset of diabetes. Only 20% of female NOD mice become diabetic by 30 weeks of age, with a later age of onset. In spite of the decrease in diabetes incidence, no differences were seen in islet histology with treated mice compared to controls. Furthermore, IL-12 treatment of recipient mice did not prevent induction of diabetes using spleen cells from diabetic mice in adoptive transfer experiments. These observations are in contrast to reported data in which treatment of NOD mice with daily doses of IL-12 exacerbated disease incidence and hastened diabetes onset.

References

Jan 1, 1992·Advances in Immunology·H Kikutani, S Makino
Apr 1, 1991·Journal of Autoimmunity·M Debray-SachsJ F Bach
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C O JacobH Acha-Orbea
May 1, 1989·The Journal of Experimental Medicine·C BoitardJ F Bach
Dec 1, 1989·Journal of Autoimmunity·D V SerrezeE H Leiter
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·X D YangH O McDevitt
Jun 25, 1993·Science·T A StewartN J MacLachlan
May 1, 1994·Clinical Immunology and Immunopathology·K J PennlineM Monahan

❮ Previous
Next ❯

Citations

Jun 26, 1999·European Journal of Immunology·P ZacconeA Cooke
Jul 31, 1998·Clinical Immunology and Immunopathology·R R Caspi
Oct 12, 2012·Diabetologia·D A Taylor-FishwickJ L Nadler
Jan 13, 2000·Current Opinion in Immunology·M Falcone, N Sarvetnick
May 10, 2003·Trends in Immunology·Ursula GrohmannPaolo Puccetti
Jun 28, 2002·Diabetes·Abdoreza Davoodi-SemiromiJin-Xiong She
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F NicolettiP Meroni
Mar 27, 2003·Nature Reviews. Immunology·S Brian Wilson, Terry L Delovitch
Jun 24, 2004·American Journal of Reproductive Immunology : AJRI·Michela ReinaErminio Giavini
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoichi OikawaTakao Saruta
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K ChenH Braley-Mullen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.