PMID: 15222403Jun 30, 2004Paper

Prevention of acute adriamycin cardiotoxicity by dantrolene in rats

Human & Experimental Toxicology
Mehmet Emin BüyükokuroğluEbubekir Bakan

Abstract

Possible preventive effect of dantrolene against the peroxidative damage in rat heart which was induced by the administration of an acute dose of adriamycin (ADR, 20 mg/kg, i.p.) has been examined. Forty-eight hours after ADR administration, biochemical changes including the activities of serum creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) and the levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in heart tissue were measured. Pretreatment of rats with dantrolene, given i.p. 30 min prior to ADR injection, substantially reduced the peroxidative damage in the myocardium, and markedly lowered the serum CK-MB, LDH and AST. The protective effects obtained by dantrolene administration, however, were not complete and did not reach those of the control group. Dantrolene, at 5 mg/kg, was useful to obtain significant protective effects, while the protector effect of higher dantrolene dosing level (10 mg/kg) was weak or absent. These results suggest that, at least in part, due to antioxidative properties, dantrolene may provide a significant protective effect against acute ADR-induced cardiotoxicity.

References

Dec 1, 1996·Journal of Neurochemistry·H Wei, D C Perry
May 1, 1997·Pediatric Hematology and Oncology·A SchiavettiV Colloridi
Jan 1, 1997·Free Radical Biology & Medicine·L Gille, H Nohl
Aug 11, 1998·Biochemical Pharmacology·X YinY J Kang
Mar 4, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M D EstevezU Schramm
Jun 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S Y SaadA C Al-Rikabi
Jun 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A GepdIremenS Oztaş
Jul 4, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K B ChakrabartiP N Plowman
Oct 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M P KostyM R Green
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M E BüyükokuroğluO I Küfrevioğlu
Jul 19, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mehmet Emin BüyükokuroğluFatma Göçer
Sep 27, 2002·Toxicology·José L QuilesM Carmen Ramírez-Tortosa

❮ Previous
Next ❯

Citations

Aug 21, 2013·Cancer Chemotherapy and Pharmacology·Duncan T VincentYuichiro J Suzuki
Aug 20, 2009·Cardiology in Review·Kuldeep Maradia, Maya Guglin
Jul 6, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ze FuShuangqing Peng
Mar 29, 2014·Redox Report : Communications in Free Radical Research·Heba A AnissCamelia Adly
Jun 6, 2012·Oxidative Medicine and Cellular Longevity·Abdelkader E AshourAbdulqader Alhaider
Apr 27, 2010·Human & Experimental Toxicology·Azhar RashikhShibli J Ahmad
Feb 9, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Urmila AswarManoj Aswar
Nov 29, 2017·Oxidative Medicine and Cellular Longevity·Donato CappettaKonrad Urbanek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.