Prevention of acute gastrointestinal complications after severe head injury: a controlled trial of cimetidine prophylaxis

American Journal of Surgery
L G HalloranJ D Miller

Abstract

Cimetidine prophylaxis significantly reduced the risk of gastrointestinal bleeding after severe head injury in this prospective, double-blind clinical trial. Cimetidine effectively reduced both the volume and the acidity of gastric secretions after brain injury without producing adverse side effects. The most common endoscopic finding was superficial, erosive, mucosal lesions in the proximal stomach. Cimetidine prophylaxis was not shown to reduce the incidence of these lesions in this study but did diminish their severity and the likelihood that they would complicate the management of these patients.

References

Apr 1, 1972·Annals of Surgery·R RobbinsG Essiet
Aug 1, 1970·Archives of Surgery·L NortonB Eiseman
Apr 1, 1971·Archives of Surgery·C E LucasA J Walt
May 1, 1969·Annals of Surgery·J A KirtleyM R Lawler
Feb 1, 1969·Journal of Neurosurgery·C C Watts, K Clark

❮ Previous
Next ❯

Citations

Jan 1, 1984·European Journal of Clinical Pharmacology·R L NationW Thompson
Feb 1, 1982·Digestive Diseases and Sciences·H G DammannB Simon
Jun 1, 1987·World Journal of Surgery·B E StabileE Passaro
Mar 1, 1981·World Journal of Surgery·H J Priebe, J J Skillman
Jan 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D E Craven, F D Daschner
Jul 13, 2011·Neurocritical Care·Clemens M SchirmerAnish Bhardwaj
Jan 1, 1984·Pharmacology & Therapeutics·R E Pounder
Jun 1, 1997·Burns : Journal of the International Society for Burn Injuries·T RaffB Hartmann
Jul 10, 1980·The New England Journal of Medicine·D S Bloom
May 21, 1981·The New England Journal of Medicine·R R Schade, R M Donaldson
Jan 17, 2009·Age and Ageing·Emma H FletcherChristopher S Gray
Sep 1, 1981·Annals of Surgery·F P StuartB L Ketel
Jan 1, 1989·Gastrointestinal Endoscopy·T H BrownG M Larson
Dec 18, 1987·The American Journal of Medicine·J W Freston
Mar 1, 1982·Surgical Neurology·O B LeramoA R Hudson
Jan 1, 1984·American Journal of Surgery·G M LarsonJ D Richardson
Feb 1, 1989·The Australian and New Zealand Journal of Surgery·K H Chan, K S Mann
Jan 1, 1986·American Journal of Surgery·S J MulvihillH T Debas
Jun 5, 2018·The Cochrane Database of Systematic Reviews·Ingrid ToewsJoerg J Meerpohl
Nov 1, 1994·Stroke; a Journal of Cerebral Circulation·E F WijdicksK P Batts
Mar 1, 1996·Stroke; a Journal of Cerebral Circulation·R J DavenportC P Warlow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.