Prevention of alcohol-induced learning deficits in fetal alcohol syndrome mediated through NMDA and GABA receptors

American Journal of Obstetrics and Gynecology
Laura TosoCatherine Y Spong

Abstract

Vasoactive intestinal peptide (VIP)-related peptides prevented the learning deficit in the offspring in a model for fetal alcohol syndrome. We evaluated whether the mechanism of the peptide protection included NR2B, NR2A, and GABAAalpha5. Timed, pregnant C57BL6/J mice were injected on gestational day 8 with alcohol (0.03 mL/kg), placebo, or alcohol plus peptides. Embryos were harvested after 6 hours, 24 hours, and on gestational day 18. Some of the litters were allowed to deliver, and the adult brains harvested after the offspring were tested for learning. Calibrator-normalized relative real-time polymerase chain reaction (PCR) was performed using primers for NR2B, NR2A, and GABAAalpha5 with GAPDH standardization. Statistic: analysis of variance (ANOVA) and Fisher PLSD, P < .05 was considered significant. In the embryo, the peptides prevented NR2B rise (P < .001) at 6 hours, NR2B down-regulation (P = .002), and GABAAalpha5 decrease (P < .01) on gestational day 18. In the adult, the peptides prevented NR2B down-regulation (P = .01) and NR2A up-regulation (P < .001). VIP-related peptides prevented alcohol-induced changes in NR2B, NR2A, and GABAAalpha5. This may explain, at least in part, the peptides' prevention of alcohol-induce...Continue Reading

References

Feb 17, 2000·Annals of the New York Academy of Sciences·P Gressens
Oct 4, 2003·American Journal of Obstetrics and Gynecology·Sarah H PoggiCatherine Y Spong
Dec 11, 2003·JAMA : the Journal of the American Medical Association·Robert J SokolBeth Nordstrom
Oct 1, 2004·Journal of Molecular Neuroscience : MN·Feng C ZhouCatherine Y Spong
Sep 15, 2005·American Journal of Obstetrics and Gynecology·M EndresC Y Spong
Oct 6, 2005·American Journal of Obstetrics and Gynecology·Laura TosoCatherine Y Spong

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Citations

May 24, 2011·Behavioural Brain Research·Morgan L KleiberShiva M Singh
Jan 4, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Maia L GreenThomas B Knudsen
Sep 11, 2007·American Journal of Obstetrics and Gynecology·Laura TosoCatherine Y Spong
Nov 24, 2012·American Journal of Obstetrics and Gynecology·Robin RobersonCatherine Y Spong
Apr 4, 2006·American Journal of Obstetrics and Gynecology·Laura TosoCatherine Y Spong
Jan 22, 2011·Obstetrics and Gynecology·Maddalena IncertiCatherine Y Spong
Jan 23, 2010·Obstetrics and Gynecology·Maddalena IncertiCatherine Y Spong
Jul 21, 2021·Biological Psychiatry·Sebastiano Bariselli, David M Lovinger

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