Prevention of antibody-mediated kidney transplant rejection

Transplant International : Official Journal of the European Society for Organ Transplantation
Christian MorathC Süsal

Abstract

There is increasing evidence that antibody-mediated rejection is the major cause of late kidney graft failure. Prevention of antibody-mediated allograft damage has therefore become an important issue in kidney transplantation. Such prevention starts already before transplantation with the avoidance of sensitizing events. When a patient is already sensitized, precise characterization of alloantibodies and exact HLA typing of the donor at the time of transplantation are mandatory. To ensure timely and successful transplantation of highly sensitized patients, desensitization, and inclusion in special programs such as the Eurotransplant Acceptable Mismatch Program should be considered. After transplantation, close monitoring of kidney function, testing for the de novo development or changing characteristics of alloantibodies, and attention to non-adherence to immunosuppression is obligatory. In the current overview, we discuss the currently available measures for the prevention of antibody-mediated kidney graft rejection.

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Citations

Nov 14, 2013·Clinical & Developmental Immunology·Qiquan Sun, Yang Yang
Dec 7, 2013·Clinical Transplantation·Kazunari Tanabe, Masashi Inui
Jan 10, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A DjamaliM Samaniego
Oct 27, 2014·Orvosi hetilap·Zsolt BodnárMaria Amador Marchante
Dec 17, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Oriol Bestard, Minnie M Sarwal
Jul 11, 2016·Transplantation Reviews·Laura A MichielsenHenny G Otten
Jul 11, 2013·Current Opinion in Organ Transplantation·Luis E BeckerChristian Morath
Sep 28, 2013·Expert Review of Clinical Immunology·Angelo A Leto BaroneGerald Brandacher
Nov 10, 2014·Orvosi hetilap·Dániel Wettstein, Dorottya Szentiványi
Apr 26, 2018·Journal of Immunology Research·Tilahun AlelignBeyene Petros
Oct 22, 2014·Current Opinion in Organ Transplantation·Sebastian FischerBohdan Pomahac
Feb 11, 2021·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Muhammad Tassaduq KhanShobha Luxmi

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