PMID: 2504119Aug 1, 1989Paper

Prevention of arrhythmias by flecainide after noncardiac thoracic surgery

The Annals of Thoracic Surgery
A BorgeatR Chioléro

Abstract

Cardiac arrhythmias are a frequent complication after thoracic operations. The prophylactic value of flecainide administered as a constant-rate, intravenous infusion (0.15 mg/kg/h) after a loading dose (2 mg/kg) was tested in a randomized, placebo-controlled study in 30 patients using Holter monitoring during the first 72 hours after operation. A high incidence of atrial and complex ventricular arrhythmias was observed in the placebo-treated group, with a clear predominance in patients undergoing left thoracotomy. Antiarrhythmic drugs had to be added in 6 patients in the placebo-treated group (n = 16), but in none in the flecainide-treated group (n = 14) (p less than 0.01). The preventive effect of flecainide was observed at serum concentrations in the middle of the therapeutic range (409 ng/mL) without side effects. It is concluded that flecainide administration effectively reduced or prevented cardiac arrhythmias after thoracic operations.

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Citations

Oct 31, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Joel DunningUNKNOWN EACTS Audit and Guidelines Committee
May 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·Artyom SedrakyanJan van der Meulen
Apr 10, 2003·The Annals of Thoracic Surgery·Koen De DeckerPaul Van Schil
May 7, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Lars P RiberHans K Pilegaard
Nov 16, 2013·Anesthesiology Research and Practice·George VretzakisMetaxia Bareka
Oct 29, 1998·Chest·S E KopecA A Conlan
Jun 1, 1991·The Annals of Thoracic Surgery·A BorgeatD Schwander
Apr 1, 1992·The Annals of Thoracic Surgery·J von KnorringO Lindfors
Mar 23, 1994·Annals of the New York Academy of Sciences·C NiederauT Heintges
Feb 23, 2019·Nature Reviews. Cardiology·Dobromir DobrevStanley Nattel
Apr 21, 2012·The Annals of Thoracic Surgery·Lars P RiberHans K Pilegaard

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