Abstract
In our previous study, we defined a cut-off point of 120 ms for atrial electromechanical interval (AEMi) to determine the risk of atrial fibrillation (AF) occurrence. Accordingly, the present study sought to investigate whether or not a prophylactic perioperative administration of amiodarone could reduce the incidence of AF in a high-risk group (AEMi >120 ms) undergoing coronary artery bypass grafting (CABG). In this prospective, randomized study, 100 patients with AEMi >120 ms received either amiodarone (n=50) or placebo (n=50). The endpoints were AF occurrence after CABG and hospital and intensive care unit (ICU) lengths of stay after CABG. The incidence of postoperative AF was significantly higher in the placebo group than that of the amiodarone group (88% of patients in control group vs. 16% of patients in amiodarone group, P<0.0001). The prophylactic therapy with amiodarone significantly reduced the ICU length of stay (2.28+/-1.00 vs. 3.60+/-0.90 days, P<0.0001) and hospital length of stay (5.64+/-2.35 vs. 7.78+/-1.46 days, P<0.0001). The incidence of postoperative AF among patients with high AEMi was significantly reduced by a prophylactic amiodarone treatment, resulting in shorter ICU and hospital stays.
References
Jan 1, 1991·American Heart Journal·S H HohnloserH Just
Nov 1, 1985·Pharmacotherapy·G V NaccarelliR A Giebel
Sep 1, 1994·The Annals of Thoracic Surgery·L L MickleboroughZ Sun
Dec 18, 1997·The New England Journal of Medicine·E G DaoudF Morady
May 19, 2001·Mayo Clinic Proceedings·T S TsangJ B Seward
Jul 3, 2002·Circulation·Eugene CrystalSalim Yusuf
Dec 12, 2003·Scandinavian Cardiovascular Journal : SCJ·Tapio Hakala, Antti Hedman
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Joseph P MathewUNKNOWN Multicenter Study of Perioperative Ischemia Research Group
Apr 22, 2005·Pharmacotherapy·Kristen A PerkersonCraig I Coleman
Dec 3, 2005·International Journal of Cardiology·Marco BudeusChristian Perings
Sep 26, 2006·The Annals of Thoracic Surgery·Brian J BarnesWilliam A Reed
Oct 26, 2006·The Annals of Thoracic Surgery·Sean M BagshawWilliam A Ghali
Oct 17, 2007·Circulation·Farideh RoshanaliFarshad Amouzadeh
Dec 25, 2007·The Annals of Thoracic Surgery·Lars R ZebisVibeke E Hjortdal
Citations
Mar 7, 2012·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Erdal AkturkHasan Pekdemir
Jan 12, 2011·Sleep & Breathing = Schlaf & Atmung·Julide YagmurHakan Tasolar
Jul 1, 2010·Anesthesia, Essays and Researches·Yasser Mohamed AmrAbd-Almohsen M Hammad
Dec 1, 2012·Clinical and Experimental Hypertension : CHE·Ruken Bengi BakalNihal Ozdemir
Feb 13, 2013·Journal of Cardiovascular Electrophysiology·Patrick MüllerAydan Ewers
Sep 11, 2010·Obesity·Julide YagmurRamazan Ozdemir
Aug 13, 2011·Pacing and Clinical Electrophysiology : PACE·Özlem EsenAli M Esen
Jun 3, 2014·BioMed Research International·Mustafa AkçakoyunMehmet Yunus Emiroğlu
Jun 3, 2014·Asian Cardiovascular & Thoracic Annals·Mohamed Ahmed Elawady, Mohamed Bashandy
Aug 8, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Adem AltunkolMustafa Topuz
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Kyle A ArsenaultRichard P Whitlock
Jan 13, 2018·Journal of Perioperative Practice·Anirban SomAnupam Goswami
Oct 19, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yongjun QianXijun Xiao