Prevention of atrial fibrillation after coronary artery bypass grafting via atrial electromechanical interval and use of amiodarone prophylaxis

Interactive Cardiovascular and Thoracic Surgery
Farideh RoshanaliBahare Saidi

Abstract

In our previous study, we defined a cut-off point of 120 ms for atrial electromechanical interval (AEMi) to determine the risk of atrial fibrillation (AF) occurrence. Accordingly, the present study sought to investigate whether or not a prophylactic perioperative administration of amiodarone could reduce the incidence of AF in a high-risk group (AEMi >120 ms) undergoing coronary artery bypass grafting (CABG). In this prospective, randomized study, 100 patients with AEMi >120 ms received either amiodarone (n=50) or placebo (n=50). The endpoints were AF occurrence after CABG and hospital and intensive care unit (ICU) lengths of stay after CABG. The incidence of postoperative AF was significantly higher in the placebo group than that of the amiodarone group (88% of patients in control group vs. 16% of patients in amiodarone group, P<0.0001). The prophylactic therapy with amiodarone significantly reduced the ICU length of stay (2.28+/-1.00 vs. 3.60+/-0.90 days, P<0.0001) and hospital length of stay (5.64+/-2.35 vs. 7.78+/-1.46 days, P<0.0001). The incidence of postoperative AF among patients with high AEMi was significantly reduced by a prophylactic amiodarone treatment, resulting in shorter ICU and hospital stays.

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Citations

Mar 7, 2012·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Erdal AkturkHasan Pekdemir
Jan 12, 2011·Sleep & Breathing = Schlaf & Atmung·Julide YagmurHakan Tasolar
Jul 1, 2010·Anesthesia, Essays and Researches·Yasser Mohamed AmrAbd-Almohsen M Hammad
Dec 1, 2012·Clinical and Experimental Hypertension : CHE·Ruken Bengi BakalNihal Ozdemir
Aug 13, 2011·Pacing and Clinical Electrophysiology : PACE·Özlem EsenAli M Esen
Jun 3, 2014·BioMed Research International·Mustafa AkçakoyunMehmet Yunus Emiroğlu
Jun 3, 2014·Asian Cardiovascular & Thoracic Annals·Mohamed Ahmed Elawady, Mohamed Bashandy
Aug 8, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Adem AltunkolMustafa Topuz
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Kyle A ArsenaultRichard P Whitlock

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