PMID: 7547714May 1, 1995Paper

Prevention of autoimmune symptoms in autoimmune-prone mice by elimination of B-1 cells

International Immunology
M MurakamiT Honjo

Abstract

Our recent studies on an autoantibody-transgenic mouse line demonstrated that peritoneal B-1 cells are responsible for autoimmune symptoms. However, whether B-1 cells in the peritoneum are generally involved in the pathogenesis of autoimmune disease remains controversial. To test the possible involvement of peritoneal B-1 cells in autoimmune symptoms of autoimmune-prone NZB mice, we eliminated the peritoneal cells by hypotonic shock with repeated i.p. injection of distilled water every 7 days into neonatal or 8-week-old NZB mice. By this treatment, B-1 cells, which self-renew within the peritoneal cavity, are expected to be preferentially eliminated, while other peritoneal cells can be easily supplied from bone marrows after this treatment. Indeed, in distilled water-treated old NZB mice, the number of B-1 cells decreased in spleen as well as in lamina propria of the gut but the numbers of conventional B cells and T cells did not change. Moreover, the production of autoantibodies against erythrocytes significantly decreased and the occurrence of autoimmune hemolytic anemia was reduced in 12-month-old treated NZB mice. Similarly, the elimination of peritoneal cells of NZB/NZW (NZB/W) F1 mice by water injection decreased anti-DNA...Continue Reading

Citations

Mar 23, 2001·Reviews in Medical Virology·H IijimaH Kiyono
Sep 9, 1998·The Journal of Experimental Medicine·A B SatterthwaiteO N Witte
Mar 19, 2003·The Journal of Experimental Medicine·Marie-Laure Santiago-RaberArgyrios N Theofilopoulos
Feb 28, 2002·Annual Review of Immunology·Robert Berland, Henry H Wortis
Oct 27, 2010·Journal of Biomedicine & Biotechnology·Toshiyuki TakaiShota Endo
Oct 2, 2013·International Immunology·Yanfei ZhangWenling Han
Apr 26, 2014·Nature Reviews. Rheumatology·Jennifer Müller, Lars Nitschke
Jun 13, 2015·International Journal of Molecular Sciences·Kongyang MaLiwei Lu
Nov 18, 2015·Molecular Immunology·Lv-Yun ZhuJian-Zhong Shao
Jul 8, 2009·Immunobiology·Mauro F Nogueira-Martins, Mario Mariano
Apr 25, 2009·Immunology Letters·Luiz Antonio De-GennaroMario Mariano
Mar 27, 2009·Immunobiology·A F PopiM Mariano
Nov 21, 2007·Immunology Letters·Beatriz H P De LorenzoMario Mariano
Jul 15, 2009·Immunological Reviews·Lars Nitschke
Jul 5, 2007·Immunology·Dass S VinayByoung S Kwon
Jan 3, 2013·Arthritis and Rheumatism·David OleksynLuojing Chen
May 23, 2013·Annals of the New York Academy of Sciences·Thomas L RothsteinHiroaki Kaku
Dec 15, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Muriel Viau, Moncef Zouali
Aug 8, 2006·Autoimmunity Reviews·Byian Duan, Laurence Morel
Jun 21, 2014·Immunological Investigations·Ronni Rômulo Novaes E BritoMario Mariano
Mar 4, 2011·Expert Opinion on Therapeutic Targets·Jayne L ChamberlainLucy Sk Walker
Jun 12, 2013·Journal of Immunotoxicology·Jean C PfauRyan Marcum
Dec 3, 2011·Journal of Immunotoxicology·Devon L Rasmussen, Jean C Pfau
Oct 8, 2013·Free Radical Biology & Medicine·Tasuku KonnoJunichi Fujii
Jan 9, 2007·Molecular Immunology·Cristina M ContrerasAnne B Satterthwaite
Jul 9, 2014·Frontiers in Immunology·Franziska FettkeAna Claudia Zenclussen
May 29, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hideaki YurinoKouji Matsushima
Apr 6, 2004·Rheumatic Diseases Clinics of North America·Elena WeinsteinBetty Diamond
Jun 19, 2004·Inhalation Toxicology·Jared M BrownAndrij Holian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Hemolytic Anemia

Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. Discover the latest research on AIHA here.