PMID: 2504682Jul 1, 1989Paper

Prevention of benzene-induced myelotoxicity and prostaglandin synthesis in bone marrow of mice by inhibitors of prostaglandin H synthase

Immunopharmacology
S J PirozziG F Kalf

Abstract

Administration of benzene to mice causes bone marrow toxicity and elevations in prostaglandin E2 (PGE2), a negative regulator of myelopoiesis. In these experiments, benzene (400 mg/kg; 2 x/day for 2 days) administered to DBA/2 or C57Bl/6 mice decreased bone marrow cellularity and myeloid progenitor cell development (measured as colony-forming units per femur) by 40%. When inhibitors of the cyclooxygenase component of prostaglandin H synthase (PHS) (either indomethacin, 2 mg/kg; aspirin, 50 mg/kg; meclofenamate, 4 mg/kg) were coadministered with benzene, myelotoxicity and the elevation in bone marrow PGE level were prevented. Additionally, when indomethacin (1 microM) was added to cultures of bone marrow cells from benzene-treated mice, myeloid progenitor cell development was the same as the controls. The doses of indomethacin used had no affect on the hepatic conversion of benzene to its major metabolite, phenol. Using purified PHS, indomethacin (10 microM) inhibited the arachidonic acid-dependent oxidation of hydroquinone to p-benzoquinone, a putative reactive metabolite of benzene. Indomethacin (10 microM) had no effect on the H2O2-driven oxidation of hydroquinone catalysed by either PHS-peroxidase or myeloperoxidase. Coadmin...Continue Reading

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L KaplanP Elsbach
Jul 1, 1979·Toxicology and Applied Pharmacology·D E RickertR D Irons
Aug 13, 1979·Life Sciences·L S AndrewsJ R Gillette
Sep 1, 1979·Journal of Toxicology and Environmental Health·D SammettR Snyder
Jan 1, 1989·Chemico-biological Interactions·M J Schlosser, G F Kalf
Oct 1, 1987·Toxicology and Applied Pharmacology·D A EastmondR D Irons
Mar 1, 1989·Mutation Research·S J PirozziG F Kalf
Jan 1, 1987·Annual Review of Cell Biology·T M Dexter, E Spooncer
Jun 30, 1988·Toxicology and Applied Pharmacology·R V BhatD Ross
Jan 1, 1985·American Journal of Industrial Medicine·M Aksoy
Oct 1, 1985·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·V V Subrahmanyam, P J O'Brien
Jan 1, 1985·Journal of Toxicology and Environmental Health·R D Irons
Dec 1, 1973·Journal of Cellular Physiology·T M DexterB I Lord
Oct 1, 1984·Toxicology and Applied Pharmacology·K Gaido, D Wierda
Sep 1, 1983·American Journal of Hematology·M Tavassoli, A Friedenstein
Sep 30, 1981·Toxicology and Applied Pharmacology·S L LongacreR Snyder
Aug 1, 1980·The Journal of Experimental Medicine·W A ScottZ A Cohn

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Citations

Jan 1, 1989·Chemico-biological Interactions·M J Schlosser, G F Kalf
Oct 1, 1995·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·D GiuntaB Melsen
Apr 1, 1993·Environmental Health Perspectives·R SnyderB D Goldstein
Jan 1, 1992·Archives of Biochemistry and Biophysics·Y C Hsuanyu, H B Dunford
Nov 20, 2013·International Journal of Occupational Medicine and Environmental Health·Joanna Kowalówka-ZawiejaKarina Sommerfeld
Dec 26, 2009·Chemico-biological Interactions·Serrine S LauTerrence J Monks
Jan 1, 1994·Critical Reviews in Toxicology·R Snyder, G F Kalf
Jun 24, 1999·Critical Reviews in Toxicology·A P DeCaprio
Jul 1, 1989·Environmental Health Perspectives·G F KalfS J Pirozzi
Jun 1, 2006·The American Journal of Sports Medicine·Allan Mishra, Terri Pavelko

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