Prevention of bleeds in hemophilia patients with inhibitors: emerging data and clinical direction

American Journal of Hematology
Cindy Leissinger

Abstract

In patients with hemophilia, the development of high-responding inhibitors to factor VIII prevents adequate replacement therapy and results in increased risk of serious bleeding episodes, poor control of joint bleeding, and progressive, debilitating joint disease. Immune tolerance therapy can eradicate inhibitors, but it is not uniformly successful. Emerging data suggest that prophylaxis using activated prothrombin complex concentrates may be effective and safe in reducing the incidence of joint bleeding during immune tolerance therapy and for patients in whom immune tolerance induction fails. However, only controlled clinical trials will ultimately demonstrate whether prophylaxis can prevent joint bleeding and damage, and improve quality of life in patients with inhibitors.

References

Jul 1, 1992·Journal of Internal Medicine·I M NilssonH Pettersson
Jan 1, 1987·Annals of the New York Academy of Sciences·J M Lusher
Jul 25, 1974·The New England Journal of Medicine·E M Kurczynski, J A Penner
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·W KreuzB Kornhuber
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Vermylen
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·D M Di Michele
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·L M Aledort, D M Dimichele
Jan 12, 1999·European Journal of Haematology. Supplementum·H H BrackmannJ Oldenburg
Aug 12, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·I ScharrerO Neutzling
Oct 26, 1999·Vox Sanguinis·P L TurecekH P Schwarz
Dec 22, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·C A Leissinger
Dec 22, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·J M Teitel
Aug 5, 2000·Seminars in Thrombosis and Hemostasis·J M Lusher
Oct 13, 2000·Drugs·A Y HoM P Smith
May 31, 2001·British Journal of Haematology·J I LorenzoJ A Aznar
Apr 16, 2002·Haemophilia : the Official Journal of the World Federation of Hemophilia·H J EhrlichE D Gomperts
Mar 18, 2003·Seminars in Thrombosis and Hemostasis·Guglielmo MarianiBarbara L Kroner
Apr 16, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·M W HilgartnerD M Dimichele
Jun 28, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Wight, S Paisley
Jun 28, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·C KnightM L Jones

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Citations

Nov 4, 2011·The New England Journal of Medicine·Cindy LeissingerLorenzo Mantovani
Aug 13, 2008·Current Opinion in Hematology·Brian BarnettCindy A Leissinger
Apr 7, 2007·Journal of Pediatric Hematology/oncology·Kimo C StineDavid L Becton
Jul 27, 2010·Expert Opinion on Emerging Drugs·Leonard A ValentinoMichele Grygotis
Nov 8, 2008·Expert Opinion on Biological Therapy·Rebecca Kruse-JarresCindy Leissinger
May 5, 2007·Expert Opinion on Biological Therapy·Yesim Dargaud, Claude Negrier
Feb 5, 2016·Thrombosis and Haemostasis·Maria Fernanda López-FernándezCarmen Sedano Balbas
Jul 24, 2015·Haemophilia : the Official Journal of the World Federation of Hemophilia·W KreuzUNKNOWN ObsITI study group and the ObsITI committee
Jan 26, 2016·Seminars in Hematology·Cindy A Leissinger
Sep 3, 2008·Thrombosis Research·Wolfhart Kreuz
Feb 8, 2016·American Journal of Hematology·Doris QuonJennifer Maahs
Mar 27, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·P A HolmeG E Tjønnfjord
Mar 27, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A ValentinoC Negrier
Mar 21, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A ValentinoC Deguzman
Aug 29, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·E SantagostinoR C R Ljung
Oct 27, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·L M Aledort
Nov 25, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·R MehtaA D Shapiro
Mar 21, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A Valentino
Nov 7, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Di PaolaC Leissinger
Jun 25, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·K FischerV Blanchette
May 15, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·J TeitelG Young
Jul 13, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·D Dimichele, C Négrier
Jan 20, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·V Jiménez-YusteF Hernández-Navarro
Jan 15, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·V Jimenez-YusteF Hernandez-Navarro
Jan 18, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·L Sieger, L Aledort
Aug 21, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·D M DiMicheleE Santagostino
Jul 21, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·S RangarajanJ Wilde
Nov 3, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A ValentinoM P Luo
Jun 5, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·A GringeriL G Mantovani
Jun 16, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·S KaveriE D Gomperts
Sep 26, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·H GelhornL Valentino
Jun 21, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·C BarnesS Dunkley
Feb 26, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·H Chambost
Feb 26, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·A ObergfellM Ezban
Feb 26, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·M Carcao, T Lambert
Dec 24, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A Valentino
May 13, 2006·Seminars in Hematology·Prasad Mathew
Jul 17, 2008·Seminars in Hematology·Victor Jiménez-YusteFernando Hernandez-Navarro
Jan 22, 2015·Haemophilia : the Official Journal of the World Federation of Hemophilia·N EwingW Kreuz
Oct 30, 2014·Journal of Thrombosis and Haemostasis : JTH·B BoylanUNKNOWN Hemophilia Inhibitor Research Study Investigators
Jul 6, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kwang-Chul Kwon, Henry Daniell

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