Prevention of bone loss with risedronate in breast cancer survivors: a randomized, controlled clinical trial

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
S L GreenspanSubashan Perera

Abstract

In postmenopausal women with low bone mass and hormone-receptor-positive breast cancer on an aromatase inhibitor, risedronate maintained skeletal health assessed by bone density and turnover markers. Women with the greatest decreases in bone turnover markers at 12 months had the greatest increases in bone density at 24 months. Aromatase inhibitors (AIs), adjuvant endocrine therapy for postmenopausal women with hormone-receptor-positive breast cancer, are associated with bone loss and fractures. Our objectives were to determine if (1) oral bisphosphonate therapy can prevent bone loss in women on an AI and (2) early changes in bone turnover markers (BTM) can predict later changes in bone mineral density (BMD). We conducted a 2-year double-blind, placebo-controlled, randomized trial in 109 postmenopausal women with low bone mass on an AI (anastrozole, letrozole, or exemestane) for hormone-receptor-positive breast cancer. Participants were randomized to once weekly risedronate 35 mg or placebo, and all received calcium plus vitamin D. The main outcome measures included BMD, BTM [carboxy-terminal collagen crosslinks (CTX) and N-terminal propeptide of type 1 procollagen (P1NP)], and safety. Eighty-seven percent completed 24 months. B...Continue Reading

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Citations

Oct 16, 2015·European Journal of Endocrinology·John Eden
Mar 5, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M R McClung
Mar 14, 2018·Endocrine-related Cancer·Tiago Vieira AugustoCristina Amaral
Feb 7, 2019·British Journal of Clinical Pharmacology·Lucia Bedatsova, Matthew T Drake
May 10, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·William D LeslieJohn A Kanis
May 15, 2020·Journal of Bone and Mineral Metabolism·Sung Hye KongChan Soo Shin
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Jul 29, 2019·Joint, Bone, Spine : Revue Du Rhumatisme·Béatrice BouvardFrançoise Debiais

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