Prevention of Breast Cancer by Natural Phytochemicals: Focusing on Molecular Targets and Combinational Strategy

Molecular Nutrition & Food Research
Yi-Shiou ChiouMin-Hsiung Pan

Abstract

Starting from the 21st century, breast cancer can be classified as the most common invasive malignancy in women. Among the preventive or therapeutic strategies of breast cancer, combination therapy is the most promising approach. This mode of treatment of breast cancer concurrently maximizes efficacy, overcomes multidrug resistance, and minimizes harmful side effects caused by radiotherapy and chemotherapy alone. The risk of cancer can be reduced by supplementing diets with naturally occurring products known as phytochemicals. These phytochemicals have well-defined roles in the management of every stage of breast carcinogenesis. In this review, the collective data of dietary phytochemicals used to sensitize breast cancer cells to therapeutic approaches are reported and their specific molecular targets through synergistic, additive, and potentiation effects are highlighted. The concept of combining natural agents with medicines to augment therapeutic responses creates an optimal modality, which may facilitate clinical applications of combination regimens in the future.

References

Mar 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Richard J SantenWei Yue
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bharat B AggarwalJanet E Price
Sep 11, 2007·Molecular Interventions·Lawrence D Mayer, Andrew S Janoff
Oct 9, 2007·Breast Cancer Research and Treatment·Christina JustenhovenHiltrud Brauch
Dec 2, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ruxandra JurcutJens-Uwe Voigt
Apr 18, 2009·Journal of Pharmacological Sciences·Neetu SinghSrikanta Kumar Rath
Feb 19, 2010·The Cancer Journal·Steven J Isakoff
Nov 9, 2010·American Journal of Surgery·Patrick MannalDavid McFadden
Nov 27, 2010·The Journal of Surgical Research·Neil BhardwajDavid M Lloyd
Dec 17, 2010·Anti-cancer Drugs·Claus LattrichOliver Treeck
Mar 15, 2011·Cancer Chemotherapy and Pharmacology·Davide StaedlerLucienne Juillerat-Jeanneret
May 28, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Qian-Mei ZhouShi-Bing Su
Oct 14, 2011·Chemical Research in Toxicology·Shabana I KhanAsok K Dasmahapatra
Mar 15, 2012·Journal of Cellular Biochemistry·Fabiana CasanovaEliane Fialho
Apr 20, 2012·Nature Reviews. Cancer·Andriy MarusykKornelia Polyak
Jun 23, 2012·Anti-cancer Agents in Medicinal Chemistry·Shi-zheng LiZhe Dong
Oct 6, 2012·Critical Reviews in Food Science and Nutrition·Laura Vera-RamirezJose L Quiles
Dec 12, 2012·Oncology Reports·Ye-Won Jeon, Young Jin Suh
Jan 1, 2013·Free Radical Biology & Medicine·Suryakant K Niture, Anil K Jaiswal
Jan 10, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min JiangKunwei Shen
Jun 5, 2013·Cold Spring Harbor Perspectives in Biology·Amanda B ParrishSally Kornbluth
Sep 10, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Bita TaghizadehBahram Goliaei
Oct 2, 2013·Indian Journal of Pharmaceutical Sciences·Anjana Mohan, S Ponnusankar
Feb 15, 2014·Chemico-biological Interactions·Mon-Yuan YangTsui-Hwa Tseng
May 14, 2014·Drug Discovery Today·Panagiota A SotiropoulouDaniele Passarella
Jun 3, 2014·Experimental Cell Research·Talia HatkevichYashomati M Patel
Sep 26, 2014·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Terézia KiskováTheresia Thalhammer
Oct 23, 2014·Journal of Cellular Biochemistry·Anya AlayevMarina K Holz

❮ Previous
Next ❯

Citations

Nov 15, 2018·International Journal of Molecular Sciences·Salvatore ChirumboloTaras Upyr
Dec 12, 2019·Critical Reviews in Food Science and Nutrition·Dinh-Chuong PhamBharath Kumar Velmurugan
May 28, 2019·Journal of Cancer Research and Clinical Oncology·Marek SamecDietrich Büsselberg
Jan 11, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sobiya ZafarFarhan Jalees Ahmad
Oct 16, 2020·International Journal of Molecular Sciences·Dong Yeong MinSoon Young Shin
Dec 22, 2021·Phytotherapy Research : PTR·Luis M Ruiz-ManriquezSujay Paul
Feb 3, 2022·Journal of Agricultural and Food Chemistry·Yike JiangQingrong Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Related Papers

Journal of Biomedical Materials Research. Part a
Nafise OlovHamid Mirzadeh
Breast Cancer : the Journal of the Japanese Breast Cancer Society
T Tajima
JAMA : the Journal of the American Medical Association
Simon Capewell, Donald M Lloyd-Jones
Pharmaceutical Science & Technology Today
R C Rowe
© 2022 Meta ULC. All rights reserved