PMID: 25792784Nov 1, 2006Paper

Prevention of carcinogenesis and cancer metastasis by bovine lactoferrin

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Hiroyuki TsudaMasaaki Iigo

Abstract

Increasing attention is being paid to chemopreventive agents for individuals at high risk of cancer. We have concentrated on bovine lactoferrin (bLF), an 80 kDa iron-binding glycoprotein known to have anti-microbial and immunoprotective effects. Lactoferrin is particularly abundant in colostrum, and is also present in tears, saliva and seminal and uterine secretions. However, only little is known regarding its influence on carcinogenesis. We have shown preventive effects of bLF and its fragment peptide, lactoferricin (bLFcin), consisting of a 25 amino acid sequence without iron binding capacity, on chemically-induced colon carcinogenesis in the rat and transplanted carcinoma cell metastasis in the mouse. The mechanisms are wide-spectrum, including elevation of caspase-1 and IL-18 in the small intestine, enhancement of the cell killing activity of cytotoxic T and natural killer (NK) cells, and anti-inflammatory and anti-angiogenic effects. It also inhibits the induction of liver CYP1A2, a carcinogen activating enzyme, and induces apoptosis in the colon epithelium of carcinogen treated rats. Thus, bLF possesses multi-functional potential to suppress carcinogenesis and is a good candidate for practical application in humans.

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Citations

Oct 4, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kiyomi Takase, Izuru Kakuta
Apr 22, 2015·Bulletin of Experimental Biology and Medicine·S D IvanovV A Yamshanov
Jun 9, 2018·Environmental Science and Pollution Research International·Mürsel KarabacakAyça Taş
Jan 21, 2021·Journal of Chemotherapy·Antonietta Arcella, Massimo Sanchez
Dec 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela Zarzosa-MorenoMireya de la Garza

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