Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Rosanna Di PaolaSalvatore Cuzzocrea

Abstract

CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-alpha play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.

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Citations

Apr 16, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·José Christian Machado XimenesGlauce Socorro de Barros Viana
Jun 1, 2011·Anais Da Academia Brasileira De Ciências·Edson N SantosDomingos T O Martins
Jun 11, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Roberta Campos LinoElson Alves Costa
Nov 25, 2005·Hematological Oncology·Manuela MollejoMiguel A Piris
Nov 24, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sally M LansleyY C Gary Lee

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