Prevention of citrate reactions during therapeutic plasma exchange by constant infusion of calcium gluconate with the return fluid

Journal of Clinical Apheresis
R Weinstein

Abstract

We have examined the effectiveness of intravenous calcium gluconate infusion in the prevention of citrate reactions during therapeutic plasma exchange. Over 3 years, 636 procedures were performed on 90 patients, mostly for treatment of neurological disorders. Return fluid consisted of 4-5% human serum albumin in 0.9% NaCl. Anticoagulant ACD-A was used at a starting ratio of 1:16. Whole blood flow rates were 70-80 ml/min. Treatments were divided into three groups for management of citrate reactions: Group A (360 treatments) were managed using simple measures only, including slowing the whole blood flow rate, altering the ACD:whole blood flow ratio, and oral calcium carbonate wafers; Group B (102 treatments) received small intravenous boluses of 10% calcium gluconate, us to 25 ml during the procedure; Group C (174 treatments) received constant infusion of calcium gluconate (10 ml/liter of return fluid) during the procedure. Citrate reactions occurred in 35.6% of Group A and 29.4% of Group B treatments (P = 0.3), but in only 8.6% of Group C treatments (P < 0.0001). Men with and without reactions were the same age (mean 63.3 vs. 61 years, P = 0.0823), but women with reactions were younger than women without reactions (mean 49.9 vs....Continue Reading

References

Aug 14, 1976·Lancet·N A BuskardM R Wills
Feb 1, 1991·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A PintoV Zagonel
Jan 1, 1990·Intensive Care Medicine·P M Reimann, P D Mason
Feb 1, 1989·Transfusion·D M SuttonG Rock
Mar 1, 1986·Transfusion·L E SilbersteinJ F Strauss
Jan 1, 1984·Journal of Clinical Apheresis·J P Hester, R Ayyar
Jan 1, 1983·Journal of Clinical Apheresis·J P HesterI O Szymanski
Jan 1, 1994·Journal of Clinical Apheresis·D Couriel, R Weinstein
Jun 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M H Mokrzycki, A A Kaplan

❮ Previous
Next ❯

Citations

Jun 20, 2002·Transfusion Medicine·Yvette F MakarJ M Serevitch
Jan 19, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·M Mörtzell HenrikssonA Wahlström
Jul 6, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Ayhan DonmezSeckin Cagirgan
Apr 29, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Mona PapariBeverly W Baron
Aug 4, 2010·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Zdenka GašováMarek Trněný
Dec 13, 2005·Journal of Clinical Apheresis·Rashmi SanjayRobert Weinstein
Dec 13, 2006·Allergy·G SterzaG G Riario-Sforza
Oct 22, 2008·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Rut NordaUNKNOWN Swedish Apheresis Group
Oct 6, 2005·Journal of Clinical Apheresis·Aftab MahmoodRobert Weinstein
Apr 14, 2012·Vox Sanguinis·L BarrA J Simpson
May 18, 2012·Transfusion·Bruce C McLeod
Apr 26, 2012·Journal of Clinical Apheresis·Grace Lee, Gowthami M Arepally
Sep 8, 2011·Journal of Clinical Apheresis·Michele H Mokrzycki, Rasheed A Balogun
Sep 2, 2010·Journal of Clinical Apheresis·Chidi OkaforRasheed A Balogun
Dec 15, 2004·Journal of Clinical Apheresis·Anneliese GonzalezRobert Weinstein
Dec 3, 2014·Transfusion·Joan CidMiguel Lozano
Sep 15, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Joan CidMiguel Lozano
Apr 15, 2000·Journal of Clinical Apheresis·R Weinstein
Feb 9, 2002·Journal of Clinical Apheresis·R Weinstein
Nov 16, 2017·Journal of Clinical Apheresis·Rachel M SirignanoErin K Meyer
Oct 14, 2017·Journal of Clinical Apheresis·Katie SiglerPoyyapakkam Srivaths
Sep 2, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Rachel M SirignanoMatthew L Paden
Sep 9, 2006·The Journal of Toxicological Sciences·Tatsuru FukudaMitsuo Nakayama
Jan 24, 2019·Journal of Clinical Apheresis·Lance A WilliamsMarisa B Marques
Jul 25, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rajesh G Krishnan, Malcolm G Coulthard
Aug 28, 2007·Journal of Clinical Apheresis·Douglas SheminMelanie Greenan
Aug 28, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Mathew Motroni, Cynthia Reilly
Mar 20, 2019·Journal of Clinical Apheresis·Mehraboon S IraniMatthew S Karafin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.