Prevention of colitis-associated cancer: natural compounds that target the IL-6 soluble receptor.

Anti-cancer Agents in Medicinal Chemistry
Cate MoriasiShrikant Anant

Abstract

The risk of developing colorectal cancer increases in patients with inflammatory bowel disease (IBD) and a growing body of evidence shows the critical role of interleukin (IL-6) in this process. IL-6 is both a pro- and anti-inflammatory cytokine whose effects are mediated through activation of STAT3. Recent studies have also demonstrated that IL-6 trans-signaling through its soluble receptor occurs in IBD and cancer. IL-6 trans-signaling therefore is emerging as an attractive approach to diminish the inflammatory signals in conditions of chronic inflammation. The purpose of cancer chemoprevention is to either delay the onset or progression from precancerous lesions. Natural compounds because of their low toxicity render themselves excellent candidates that can be administered over the lifetime of an individual. With the focus of managing IBD over a long time and preventing onset of colitis-associated cancer, we believe that there should be increased research focus on identifying chemopreventive compounds that can render themselves to long term use possibly for the lifetime of predisposed individuals. Here, we review the role of IL-6 signaling in IBD and colitis-associated cancer and underscore the importance of searching for na...Continue Reading

Citations

Apr 29, 2014·Toxicology and Applied Pharmacology·Lu FanQiang Xu
Aug 6, 2014·International Journal of Inflammation·Hang YangGuanglin Cui
Aug 27, 2016·International Journal of Molecular Sciences·Xiaowei HuoLi Cao
May 25, 2013·World Journal of Gastroenterology : WJG·Hiroshi MiyazakiW Andrew Yeudall
Oct 13, 2020·Frontiers in Pharmacology·Ye-Seul KimYoung-Guen Kwon
Feb 6, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Massimo Claudio Fantini, Ilaria Guadagni
Jan 30, 2021·Food Research International·Roberto de Paula do NascimentoMário Roberto Maróstica Junior

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here