Prevention of collagen deposition following pulmonary oxygen toxicity in the rat by cis-4-hydroxy-L-proline

The Journal of Clinical Investigation
D J RileyD J Prockop

Abstract

Exposure of rats to high oxygen tensions causes increased collagen content of lungs and alveolar enlargement in 3-6 wk. We tested whether cis-hydroxyproline, a proline analogue that inhibits collagen synthesis, could prevent the collagen accumulation and alveolar enlargement. Rats were exposed to hyperoxia for 60 h and then to room air and hyperoxia for alternate 24-h periods for 11.5 d. Treated oxygen-exposed rats received 200 mg/kg cis-hydroxyproline twice daily over the 14-d exposure period. Control rats breathed room air. Examination of lungs on day 14 showed collagen content of oxygen-exposed lungs to be 48% greater than control (P < 0.05). The collagen content of the treated oxygen-exposed lungs was -12% of control (NS). Total lung volume was 16% greater than control in oxygen-exposed rats (P < 0.05) and 8% greater than control in treated oxygen-exposed rats (NS). Morphometric studies showed alveolar size was greater than control in oxygen-exposed rats (188+/-11 [SE] vs. 143+/-6 mumul [P < 0.05]). Oxygen-exposed, treated rats had a mean alveolar volume of 150+/-7 mumul. Lung pressure-volume curves were significantly shifted to the left of control in the oxygen-exposed rats, whereas the curves of the oxygen-exposed, treate...Continue Reading

References

Mar 1, 1975·The Journal of Clinical Investigation·K BradleyR G Crystal
Jul 5, 1979·The New England Journal of Medicine·D J ProckopN A Guzman
Sep 1, 1976·Journal of Applied Physiology·V Richmond, B G D'Aoust
Nov 1, 1975·Archives of Environmental Health·M Chvapil, Y M Peng
Jan 1, 1974·Journal of Supramolecular Structure·K A Piez, A Miller
May 11, 1973·Science·M L Tanzer
Apr 1, 1974·The Anatomical Record·P H BurriE R Weibel
Mar 1, 1973·The Journal of Clinical Investigation·G Gacad, D Massaro
Jul 1, 1969·The Journal of Clinical Investigation·J C HoggW M Thurlbeck
May 1, 1967·Analytical Biochemistry·K I KivirikkoD J Prockop

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Citations

Jun 20, 2013·Applied Microbiology and Biotechnology·Thi Mai Hoa Bach, Hiroshi Takagi
Apr 5, 1984·Biochimica Et Biophysica Acta·M J Wilson, D L Hatfield
Dec 30, 1988·Toxicology·L S GeismarD J Riley
Jan 1, 1990·Experimental Gerontology·J S KerrD J Riley
Apr 15, 1982·The New England Journal of Medicine·J E Rinaldo, R M Rogers
Jul 25, 2008·The Journal of Biological Chemistry·Hye Jin ChungAndrzej Fertala
Apr 1, 1989·The American Review of Respiratory Disease·C M ParentiD E Niewoehner
Aug 1, 1989·The American Review of Respiratory Disease·J E Heffner, J E Repine
Dec 1, 1994·American Journal of Respiratory and Critical Care Medicine·G L SniderP J Stone
Dec 25, 2012·Fibrogenesis & Tissue Repair·Andrzej Steplewski, Andrzej Fertala
Jan 1, 1987·Experimental Lung Research·G M King, I Y Adamson
Aug 1, 1988·The American Journal of the Medical Sciences·S UmekiR Soejima
May 15, 2012·Journal of Bioscience and Bioengineering·Bach Thi Mai HoaHiroshi Takagi
Sep 30, 1984·Toxicology and Applied Pharmacology·D J RileyS Y Yu
Oct 1, 1987·Experimental and Molecular Pathology·R A DurrL A Thet
Dec 21, 2006·Phytotherapy Research : PTR·Feng-Lin YenChun-Ching Lin
Jan 1, 1991·Annals of the New York Academy of Sciences·G L SniderE C Lucey
May 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J P IannottiM Staum
Apr 15, 1990·International Journal of Cancer. Journal International Du Cancer·W C ReevesL Whitesell
Nov 23, 2019·International Journal of Biological Macromolecules·M VisalatchiGanesh Shanmugam
Jul 23, 1982·Science·D E Niewoehner, J R Hoidal

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