Prevention of congenital toxoplasmosis in Szeged, Hungary

International Journal of Epidemiology
Z SzénásiC Verhofstede

Abstract

Toxoplasma gondii infection of the fetus can only be discovered or prevented by the appropriate serological screening and subsequent treatment of the mother and her offspring. In Hungary, there is no obligatory toxoplasma screening for pregnant women and both the reporting and follow-up of congenital toxoplasmosis cases is limited. In 1987 we started a systematic study in the Szeged region of Hungary, in which all pregnant women were screened and appropriate treatment given to all mothers and their offspring where congenital toxoplasmosis was suspected. All pregnant women were routinely screened within the first 16 weeks of gestation for toxoplasma antibodies by complement fixation test (CFT). Seronegative cases were retested for possible seroconversion every second month. Patients with CFT titres > or = 1:256 were retested for anti-P30 immunoglobulin A (IgA), IgM and IgG antibodies by ELISA and/or SDS-PAGE-Western immunoblot in order to distinguish the acute and chronic phases of the infection. Up to the end of 1994, the sera of 17,735 gravidae were screened. Ten women were found to have seroconverted during pregnancy and 78 had high initial antibody levels accompanied by anti-P30 IgA antibodies at the very first screening. Th...Continue Reading

Citations

Oct 4, 2006·Proceedings. Biological Sciences·Kevin D Lafferty
Sep 9, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Mohamed Alkhatim Alsammani
Sep 22, 2011·Wiener klinische Wochenschrift·Branko BobićOlgica Djurković-Djaković
Jan 16, 2007·Lancet·UNKNOWN SYROCOT (Systematic Review on Congenital Toxoplasmosis) study groupRuth Gilbert
Mar 5, 2005·The American Journal of Medicine·Jeffrey D Kravetz, Daniel G Federman
Feb 7, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bálint NagyZoltán Papp
Apr 9, 2015·Infectious Diseases·Tudor Rares OlariuOctavian Mazilu
Mar 30, 2000·Primary Care·E H Morrison

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