Prevention of corneal allograft rejection in a mouse model of high risk recipients

The British Journal of Ophthalmology
A VítováV Holán

Abstract

To determine the effectiveness of treatment with immunosuppressive drugs and monoclonal antibodies (mAb) after penetrating keratoplasty in two different models of high risk mouse recipients. Corneas were grafted orthotopically in mouse models of high risk recipients with either neovascularisation of the graft bed or presensitisation to graft donor antigens. Recipients were treated with mAb against CD4(+) or CD8(+) cells or against T cells, or were treated with cyclosporin A (CsA) or mycophenolate mofetil (MMF), or a combination of both drugs. Control untreated recipients with neovascularised graft bed or presensitised to the graft donor antigens rejected corneal allografts in 12.5 (SD 2.3) and 9.9 (1.6) days, respectively. Treatment of graft recipients with a neovascularised graft bed with mAb anti-CD4 or anti-T cells, but not with mAb anti-CD8 or with immunosuppressive drugs, resulted in a significant prolongation of graft survival; 75% and 28.5%, respectively, of grafts survived for more than 45 days after grafting. However, none of the treatments were successful in presensitised recipients. Treatment of high risk recipients with mAb anti-CD4 is more effective in preventing corneal allograft rejection than the treatment with ...Continue Reading

References

Oct 1, 1992·The British Journal of Ophthalmology·W AyliffeI V Hutchinson
Jul 1, 1988·Transplantation·J C Hill, R Maske
Mar 1, 1980·The British Journal of Ophthalmology·W F ShepherdB R Jones
Nov 27, 1999·The British Journal of Ophthalmology·L KuffováM Filipec
Dec 28, 1999·The British Journal of Ophthalmology·A D DickJ D Isaacs
Aug 3, 2001·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T ReinhardR Sunmacher
Dec 6, 2001·The British Journal of Ophthalmology·A C PoonR J Buckley
Jan 22, 2002·The British Journal of Ophthalmology·J PlskováJ V Forrester
Feb 1, 2002·Transplantation·Jarmila PlskováJohn V Forrester
Apr 6, 2002·Transplant International : Official Journal of the European Society for Organ Transplantation·M KrulováV Holán

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Citations

Feb 13, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Andrea VitovaJohn V Forrester
May 5, 2005·Immunology Letters·Vladimír HolánJohn V Forrester
Dec 3, 2014·Experimental Eye Research·Susan M NichollsAndrew D Dick
Jan 1, 2006·Expert Review of Clinical Immunology·Vladimír Holán

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