Prevention of deoxynivalenol- and zearalenone-associated oxidative stress does not restore MA-10 Leydig cell functions

Toxicology
Christian SavardYounes Chorfi

Abstract

The worldwide contamination of grains designated to human and animal feeding with Fusarium mycotoxins is a significant problem. Among Fusarium mycotoxins, deoxynivalenol (DON) and zearalenone (ZEA) are the most prevalent mycotoxins found in cereals. Co-occurrence of DON and ZEA is also very frequent and indicates that these mycotoxins might be involved in a wide range of synergistic or additive interactions. Both mycotoxins have been linked to various male reproduction problems including downregulation of steroidogenesis. In this study, the impact of DON and ZEA alone or in combination on the viability and steroid production of Leydig cell line MA-10 was determined. The ability of vitamin E, sesamin and their combination to prevent oxidative stress and restore progesterone secretion in DON- and ZEA-exposed cells was also determined. Results showed that MA-10 cells were more sensitive to the effect of DON compared to ZEA. DON and ZEA also significantly reduced MA-10 progesterone secretion after forskolin activation but no significant interactions between DON and ZEA were detected. Preventive treatment with the combination of vitamin E and sesamin significantly reduced ROS production and increased cell survival after exposition t...Continue Reading

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Oct 25, 2016·Environmental Toxicology and Pharmacology·Karolina KowalskaAgnieszka Wanda Piastowska-Ciesielska
Apr 4, 2018·Journal of Applied Toxicology : JAT·Kinga Anna UrbanekAgnieszka Wanda Piastowska-Ciesielska
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Apr 2, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Xichun WangJinjie Wu
Sep 15, 2021·Critical Reviews in Food Science and Nutrition·Silu HouYaxian Yan

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