PMID: 9642642Jun 27, 1998Paper

Prevention of diabetes in non-obese diabetic (NOD) mice by short-term and high-dose IGF-I treatment

Journal of Pediatric Endocrinology & Metabolism : JPEM
Y KainoK Kida

Abstract

This report describes the results of IGF-I treatment in a NOD mouse colony with a high incidence of overt diabetes. The animals were treated with IGF-I 17.9 nmol/day at 28-41 days of age and 35.9 nmol/day at 42-69 days of age and observed up to 280 days of age. Three of 12 (25%) IGF-I-treated animals developed diabetes compared with 8 of 11 (73%) controls (P < 0.05). The severity of insulitis at the conclusion of the follow-up was less pronounced in non-diabetic treated animals than in non-diabetic controls. These data support previous findings that IGF-I treatment protects the pancreatic beta-cells from destruction by diabetic autoimmunity in NOD mice.

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Z J ZhangH L Weiner
Jan 1, 1980·Jikken dobutsu. Experimental animals·S MakinoY Tochino
Jul 1, 1995·Diabetes·P Gladstone, G T Nepom
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D Daniel, D R Wegmann
Sep 1, 1996·Diabetes Research and Clinical Practice·Y KainoK Kida

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