Prevention of disease progression in Leishmania infantum-infected dogs with dietary nucleotides and active hexose correlated compound

Parasites & Vectors
Sergi SegarraJ J Cerón

Abstract

The prevalence of Leishmania infantum infection in clinically healthy dogs can be several times higher than that of clinical disease in endemic areas. Although treatment is not recommended in dogs with subclinical infection, these animals should be managed to prevent disease progression and parasite transmission to human beings or to other dogs. Dietary nucleotides and active hexose correlated compound (AHCC) have been shown to modulate the immune response. A recent study in dogs with clinical leishmaniosis receiving an initial 28-day course of methylglucamine antimoniate showed that six-month administration of a dietary supplement containing nucleotides plus AHCC achieves similar efficacy to allopurinol. Since the type of immune response plays a key role in the evolution of patients with leishmaniosis, the present study was aimed at evaluating the preventive effect of this supplement in avoiding or delaying disease progression in clinically healthy Leishmania-infected dogs. Forty-six dogs were included in this multicenter, randomized, double-blind, placebo-controlled trial. Dogs received once-daily oral administration of a placebo or a dietary supplement containing nucleotides plus AHCC. Disease progression was monitored throu...Continue Reading

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Citations

Nov 20, 2019·Emerging Infectious Diseases·Filipe Dantas-TorresDomenico Otranto
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Jul 8, 2019·Research in Veterinary Science·Marta BaxariasLaia Solano-Gallego
Jan 18, 2022·Journal of Veterinary Internal Medicine·María-Dolores TabarMari-Carmen Rodríguez

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Methods Mentioned

BETA
enzyme-linked
PCR
ELISA

Software Mentioned

SPSS Statistics

Related Concepts