Prevention of Encrustation on Ureteral Stents: Which Surface Parameters Provide Guidance for the Development of Novel Stent Materials?

Polymers
Henrike ReblJ Barbara Nebe

Abstract

Encrustations of ureteral stents are one of the biggest problems with urological implants. Crystalline biofilms can occur alone or in combination with bacterial biofilms. To identify which surface parameters provide guidance for the development of novel stent materials, we used an in vitro encrustation system. Synthetic urine with increasing pH to simulate an infection situation was pumped over the polymer samples with adjusted flow rates at 37 °C to mimic the native body urine flow. Chemical surface features (contact angle, surface charge), as well as encrustations were characterized. The encrustations on the materials were analyzed quantitatively (dry mass) and qualitatively using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and Fourier transform infrared spectroscopy (FTIR). The aim of this comparative study was to identify crucial surface parameters that might predict the quantity and type of mineral deposits in vitro and provide guidance for the development and screening of new polymer-based biomaterials for ureteral stent design. For the first time, we could identify that, within the range of our polymers, those materials with a slight hydrophilicity and a strong negative zeta potential ...Continue Reading

References

May 1, 1978·Kidney International·D P Griffith
Apr 1, 1988·The Journal of Hospital Infection·A B MulhallR A Crow
Aug 1, 1996·Biomaterials·M M TunneyS P Gorman
Jul 13, 2002·The American Journal of Medicine·Betsy Foxman
Jul 24, 2002·International Journal of Antimicrobial Agents·K-H BichlerS Lahme
Jul 24, 2002·International Journal of Antimicrobial Agents·Claus R RiedlHeinz Pflueger
Aug 12, 2003·Pathology, Research and Practice·R Lagier, C A Baud
Feb 14, 2006·Nature Clinical Practice. Urology·Ben H Chew, John D Denstedt
Dec 5, 2006·Water Research·Kristell S Le CorreSimon A Parsons
May 29, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Norbert LaubeChristian Fisang
Feb 10, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Andrew P Evan
Feb 22, 2011·The Journal of Urology·Thomas KnollGernot Schubert
Mar 5, 2016·Biomedizinische Technik. Biomedical Engineering·Norbert LaubeFalk Bernsmann
Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Jing ZhaoKe Yang
Nov 9, 2018·Journal of Healthcare Engineering·Yvonne J CorteseAndrew Fogarty
Dec 24, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Joseph Km LiChi-Fai Ng

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Methods Mentioned

BETA
Electrophoresis
scanning electron microscopy
X-ray
Infrared Spectroscopy
ELISA

Software Mentioned

GraphPad PRISM
QUANTAX ESPRIT microanalysis
GraphPad

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