PMID: 7018898Apr 1, 1981Paper

Prevention of endotoxin-induced arterial hypoxaemia and lactic acidosis with flunixin meglumine in the conscious pony

Equine Veterinary Journal
J N MooreD G Hatfield

Abstract

Bacterial endotoxin injected intravenously into conscious ponies produced alterations in cardiopulmonary and gastrointestinal function. Specifically, tachypnoea, dyspnoea, hypoxaemia, colic, lactic acidosis and diarrhoea resulted from administration of 10 micrograms/kg Escherichia coli endotoxin. Pretreatment of the ponies with a potent prostaglandin synthetase inhibitor, flunixin meglumine, prevented these ill effects of endotoxin.

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Citations

Jun 1, 1984·Archives of Biochemistry and Biophysics·K L OlgiatiW A Toscano
May 1, 1987·Prostaglandins, Leukotrienes, and Medicine·S D Semrad, J N Moore
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