Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1.

Investigative Ophthalmology & Visual Science
Umesh C S YadavKota V Ramana

Abstract

To study the amelioration of ocular inflammation in endotoxin-induced uveitis (EIU) in rats by benfotiamine, a lipid-soluble analogue of thiamine. EIU in Lewis rats was induced by subcutaneous injection of lipopolysaccharide (LPS) followed by treatment with benfotiamine. The rats were killed 3 or 24 hours after LPS injection, eyes were enucleated, aqueous humor (AqH) was collected, and the number of infiltrating cells, protein concentration, and inflammatory marker levels were determined. Immunohistochemical analysis of eye sections was performed to determine the expression of inducible-nitric oxide synthase (iNOS), cyclooxygenase (Cox)-2, protein kinase C (PKC), and transcription factor NF-kappaB. Infiltrating leukocytes, protein concentrations, and inflammatory cytokines and chemokines were significantly elevated in the AqH of EIU rats compared with control rats, and benfotiamine treatment suppressed these increases. Similarly increased expression of inflammatory markers iNOS and Cox-2 in ciliary body and retinal wall was also significantly inhibited by benfotiamine. The increased phosphorylation of PKC and the activation of NF-kappaB in the ciliary body and in the retinal wall of EIU rat eyes were suppressed by benfotiamine....Continue Reading

Associated Clinical Trials

Citations

Feb 14, 2012·International Journal of Rheumatic Diseases·Ashit SynglePrem Chand
Oct 1, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Y DuT S Kern
Jan 31, 2012·Expert Opinion on Investigational Drugs·Saumya PandeyKota V Ramana
Mar 7, 2013·CNS Neuroscience & Therapeutics·Khanh V Q Luong, Lan T H Nguyễn
Mar 6, 2012·Journal of the Neurological Sciences·Khanh vinh quôc Lu'o'ng, Lan Thi Hoàng Nguyên
Jan 1, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Khanh vinh quốc L Ng, Lan Thi Hoàng Nguyễn
May 14, 2016·The Journal of Veterinary Medical Science·Kazutaka KanaiNaoyuki Itoh
Apr 22, 2016·The Journal of Veterinary Medical Science·Kazutaka KanaiNaoyuki Itoh
Jul 29, 2017·Expert Opinion on Pharmacotherapy·Uwe PleyerReinhold Kreutz
May 7, 2011·Biomolecular Concepts·Kota V Ramana
Mar 21, 2019·Pharmaceutical Development and Technology·Mitra Alami-MilaniMitra Jelvehgari
Sep 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Richard Frederick PorterMelanie E M Kelly

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Investigative Ophthalmology & Visual Science
Umesh C S YadavKota V Ramana
Investigative Ophthalmology & Visual Science
Nilesh M KalariyaKota V Ramana
Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
H StrackeK F Federlin
© 2021 Meta ULC. All rights reserved