Prevention of experimental cancer and immunostimulation by vitamin E (immunosurveillance)

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
G ShklarS Reid

Abstract

Eighty young adult male Syrian hamsters were divided into four equal groups. Group 1 animals had the right buccal pouches painted with a 0.1% solution of 7,12 dimethylbenz(a)anthracene (DMBA) three times per wk for 28 wk. Group 2 animals were similarly painted with DMBA for 28 wk but were also given 140 micrograms vitamin E in 0.4 ml mineral oil three times weekly on days alternate to DMBA painting. Group 3 animals were used as DMBA-vehicle controls. Group 4 animals were vitamin E controls. Animals were killed after 28 wk, the pouches photographed and tumors counted, measured. The pouches were fixed in formalin, sectioned in paraffin and studied histologically and histochemically for tumor necrosis factors alpha and beta. All animals in Group 1 and 3 had gross tumors of the right buccal pouch. None of the animals in Group 2 had grossly visible tumors. Microscopic studies revealed that, while no gross tumors were seen in the Group 2 animals, there was histologic evidence of dysplasia and early carcinoma-in-situ undergoing degeneration. Immunohistochemical staining revealed a dense infiltrate of mononuclear cells adjacent to tumor sites with a large number of cytotoxic T lymphocytes and macrophages. Vitamin E appears to prevent t...Continue Reading

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Citations

Nov 1, 1992·Journal of Surgical Oncology·R PillaiR R Watson
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·B A TeicherD Northey
Jan 1, 1993·European Journal of Cancer. Part B, Oral Oncology·G Shklar, J Schwartz
Oct 1, 1993·European Journal of Cancer. Part B, Oral Oncology·J SchwartzD Trickler
Jan 1, 1995·European Journal of Cancer. Part B, Oral Oncology·T Tanaka
Mar 1, 1996·European Journal of Cancer. Part B, Oral Oncology·G Shklar, J L Schwartz
Aug 1, 1995·Critical Reviews in Oncology/hematology·B A Teicher
Nov 15, 1996·European Journal of Biochemistry·G H Werner, P Jollès
Dec 31, 1993·Annals of the New York Academy of Sciences·L A LambertA Kornhauser
May 28, 1993·Annals of the New York Academy of Sciences·J L SchwartzS Zhao
Feb 7, 2001·Cancer Investigation·G Shklar, S K Oh
Apr 1, 1992·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J Schwartz, G Shklar
Jul 26, 2011·Periodontology 2000·Newell W JohnsonA A Hemantha K Amarasinghe
Apr 23, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hemantha K AmarasingheSaman Warnakulasuriya
Jan 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T M elAttar, H S Lin
Oct 1, 1994·Oral Surgery, Oral Medicine, and Oral Pathology·G E KaugarsJ Gallo
Apr 4, 2006·Otolaryngologic Clinics of North America·Kevin S Brown, Madeleine A Kane
Jan 1, 1992·Cancer Chemotherapy and Pharmacology·J L SchwartzB A Teicher

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