Prevention of filtering surgery failure by subconjunctival injection of a novel peptide hydrogel into rabbit eyes

Biomedical Materials
Liang LiangFa-Gang Jiang

Abstract

A novel biocompatible hydrogel was prepared based on the supramolecular self-assembly of a peptide containing a bioactive RGD (arginine-glycine-aspartic acid) sequence and a hydrophobic N-fluorenyl-9-methoxycarbonyl (FMOC) tail. When the self-assembled peptide hydrogel was administered after the filtering surgery of rabbit eyes, the level of connective tissue growth factor (CTGF) mRNA as well as the mean intraocular pressure (IOP) was significantly lower than that of the control eyes during the 21 postoperative days. The filtration bleb and ultrasound biomicroscopy (UBM) images showed that a patent bleb and a filtration fistula could be found in the surgical site of a rabbit eye during the whole experimental period. Histological analysis further evidenced that the filtering surgical wound healing was a normal healing process without scar formation. This new approach, making use of a self-assembled peptide hydrogel to normalize filtering surgical wound healing, may have potential for glaucoma filtering surgery.

References

Dec 1, 1991·Archives of Ophthalmology·T J BergstromV M Elner
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·I V YannasG F Murphy
Apr 1, 1984·Ophthalmology·D K HeuerD R Anderson
Jan 20, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·I V Yannas
Aug 31, 2000·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·K WunderlichP Meyer
May 11, 2002·Journal of the American Academy of Dermatology·Omar Lupi
Jul 23, 2002·Nature Cell Biology·José G AbreuE M De Robertis
Feb 28, 2003·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Gysbert van SettenGregory Schultz
Apr 26, 2003·Investigative Ophthalmology & Visual Science·Timothy D BlalockGregory S Schultz
May 15, 2003·Survey of Ophthalmology·Paul J Lama, Robert D Fechtner
Jun 6, 2003·Clinical & Experimental Ophthalmology·Cengiz AkarsuBerati Hasanreisoglu
Oct 2, 2003·Nature Biotechnology·Shuguang Zhang
Oct 11, 2003·Biotechnology Advances·Shuguang Zhang
Jan 28, 2004·Investigative Ophthalmology & Visual Science·Douglas W EssonMark B Sherwood
Jun 17, 2004·Journal of the American Chemical Society·Christine KeyesP Chen
Jul 20, 2004·Nature Biotechnology·Sunil ShaunakSteve Brocchini
Feb 20, 2007·Chemical Communications : Chem Comm·Zhimou YangBing Xu
Mar 13, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Liang LiangRen-Xi Zhuo

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Citations

Apr 15, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Deborah M WallaceColm J O'Brien
May 30, 2013·Journal of Biomaterials Science. Polymer Edition·Xing-Hua WangFa-Gang Jiang
Aug 7, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jiaxi CuiAránzazu del Campo
Apr 14, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Baoji ChenNa Xu

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