Prevention of HBV reactivation in patients treated with biologic agents

Expert Review of Clinical Pharmacology
Christos KoutsianasDimitrios Vassilopoulos

Abstract

Owing to the sensitive equilibrium between the hepatitis B virus (HBV) and the host's immune system in infected and exposed individuals, the immunosuppression caused by biologic treatment has been strongly linked to HBV reactivation (HBVr). HBVr in the setting of biologic therapy is a cause of considerable morbidity, hospitalization, interruption of treatment and mortality. However, recent literature has established that this is a largely preventable problem. Thus, it is essential for clinicians using biologic agents to be aware of HBVr potential and screen all susceptible patients. The risk for HBVr may vary depending on the host's HBV infection status and the potency of immunosuppression. The appropriate pre-emptive antiviral prophylaxis or monitoring for individuals at risk is emphasized in the latest evidence-based guidelines, but a number of unanswered questions remain.

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Citations

Nov 16, 2018·The Journal of Dermatological Treatment·Kerasia-Maria Plachouri, Sophia Georgiou
Sep 9, 2016·World Journal of Gastroenterology : WJG·Claudio BonifatiLorenzo Nosotti
Sep 11, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Marie-Laure CambierKarine Dahan
Jan 21, 2021·European Journal of Gastroenterology & Hepatology·Salvatore MagrìGiammarco Mocci
Sep 4, 2021·Internal and Emergency Medicine·Michele BaroneGiuseppe Lopalco
Dec 19, 2021·Dermatologic Therapy·Elżbieta Halina KłujszoAnna Witkowska

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