PMID: 1450479Oct 1, 1992

Prevention of hemodialysis associated hypoxemia by use of low-concentration bicarbonate dialysate

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
R GanssG Nordby


Hypoxemia during acetate dialysis is caused by hypoventilation due to bicarbonate loss across the dialyzer and its regeneration from acetate by a CO2 consuming process. Loss of bicarbonate is prevented by using a bicarbonate containing dialysate, but hypoxemia is still found by many authors. In the current study, ten patients were dialyzed twice against acetate dialysate, high concentration bicarbonate (36 mmol/L), and low concentration bicarbonate (29 mmol/L) dialysates. A significant decrease in PO2 was found during both acetate and high concentration bicarbonate dialysis. Hypoxemia was prevented by low concentration bicarbonate dialysate. A possible explanation for the hypoxemia in high concentration bicarbonate dialysis may be hypoventilation induced by alkalosis. It was concluded that low concentration bicarbonate dialysate prevents hypoxemia during hemodialysis.


Mar 14, 2008·Journal of Renal Care·Karen Latchford, Jan Cowperthwaite
Jul 9, 2004·Advances in Chronic Kidney Disease·F Dumler, Peter A McCullough

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